ID A0A0K0EQ01_STRER Unreviewed; 310 AA.
AC A0A0K0EQ01;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Arginase {ECO:0000256|ARBA:ARBA00018123};
DE EC=3.5.3.1 {ECO:0000256|ARBA:ARBA00012168};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0001153000.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0001153000.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-ornithine + urea; Xref=Rhea:RHEA:20569,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:46911; EC=3.5.3.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000227};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-
CC arginine: step 1/1. {ECO:0000256|ARBA:ARBA00005098}.
CC -!- SIMILARITY: Belongs to the arginase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00742}.
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DR AlphaFoldDB; A0A0K0EQ01; -.
DR STRING; 6248.A0A0K0EQ01; -.
DR WBParaSite; SSTP_0001153000.1; SSTP_0001153000.1; SSTP_0001153000.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0004053; F:arginase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006525; P:arginine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0000050; P:urea cycle; IEA:UniProtKB-KW.
DR CDD; cd09989; Arginase; 1.
DR Gene3D; 3.40.800.10; Ureohydrolase domain; 1.
DR InterPro; IPR014033; Arginase.
DR InterPro; IPR006035; Ureohydrolase.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR43782; ARGINASE; 1.
DR PANTHER; PTHR43782:SF3; ARGINASE; 1.
DR Pfam; PF00491; Arginase; 1.
DR PRINTS; PR00116; ARGINASE.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
DR PROSITE; PS51409; ARGINASE_2; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503};
KW Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW Urea cycle {ECO:0000256|ARBA:ARBA00022436}.
SQ SEQUENCE 310 AA; 34539 MW; AD1293E85C1F7EDB CRC64;
MRLTLKFLSK QLNLIGLANG YGGRHLGCEE AVKVLKNSSI FKECKIPYKW NSIIEETVTG
RSVNALEGVI KNSQQLCNET ARFVKENEEL LVIGGDHSSA IGTWSGVATA LRSKGDIGLL
WVDAHMDSHT FETSFTGNIH GMPVAHLLGF GNDKLTTIGD NFPKIKPSNL ALVGIRSYEP
AEEKLLTSLG VKIFYMKDVH KYGLDKCMEK AIERISENTI GYGMSIDIDS FRVEDAPAVG
TPEDDGIVAV EFMNFIKNAN LDKLLVTEIV EFMPKKDDEN KKSEKLVKKL VESIYEKRFK
KNTLLSYNVL
//
