ID   A0A0K0ES07_STRER        Unreviewed;       446 AA.
AC   A0A0K0ES07;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Nuclear receptor domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Strongyloides stercoralis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0001223600.1};
RN   [1] {ECO:0000313|WBParaSite:SSTP_0001223600.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC       {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
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DR   AlphaFoldDB; A0A0K0ES07; -.
DR   STRING; 6248.A0A0K0ES07; -.
DR   WBParaSite; SSTP_0001223600.1; SSTP_0001223600.1; SSTP_0001223600.
DR   Proteomes; UP000035681; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd06960; NR_DBD_HNF4A; 1.
DR   CDD; cd06157; NR_LBD; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   InterPro; IPR049636; HNF4-like_DBD.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR46587; NUCLEAR HORMONE RECEPTOR FAMILY; 1.
DR   PANTHER; PTHR46587:SF7; NUCLEAR HORMONE RECEPTOR FAMILY MEMBER NHR-19; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT   DOMAIN          25..100
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          182..444
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   446 AA;  52189 MW;  9CF9B8F7A06AC7E5 CRC64;
     MNKKESILKN YSPNREKNPT TSKVIGSCLI CGEESTGKHY GIISCLGCKT FFRRAVVHHQ
     GLNCKRQGKC ILEKNARKTC RGCRYRKCLE MGMSKDALQP RRDLIGCRKV NRNVSKYVNN
     NEKLKSFNNN NNNNNLSSQV IPSQSNDFNR QNKELLYFII KLTKRDRDIR ERKYESLKCQ
     LEMKNLAEQL NNFNEINKNN NYTTVPYDIS PTTDKLKIML AEDIAKVCSM ELISMIEWAR
     TLPCFSQLPI NDQLVLLKRY AVQHLILEHG YYTSQFNYND VWMISNGTCM PRNCNPSNNN
     FIDNCTEDRR WRQEKLYKQM TERCIDEVVA PLKHLKLMPE ELLTLKISML YQCGNHLSDT
     ESTLAISKRS RKLIIEARER CYKALFLFYK HIKYKNYEER FGNVILTISG IVSAASAVQE
     SYQIMRLFKI VPFDHLAEQL LFHINE
//