ID A0A0K0ETM2_STRER Unreviewed; 679 AA.
AC A0A0K0ETM2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
OS Strongyloides stercoralis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=6248 {ECO:0000313|WBParaSite:SSTP_0001279800.1};
RN [1] {ECO:0000313|WBParaSite:SSTP_0001279800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
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DR AlphaFoldDB; A0A0K0ETM2; -.
DR STRING; 6248.A0A0K0ETM2; -.
DR WBParaSite; SSTP_0001279800.1; SSTP_0001279800.1; SSTP_0001279800.
DR Proteomes; UP000035681; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46257; TYROSINE-PROTEIN PHOSPHATASE CORKSCREW; 1.
DR PANTHER; PTHR46257:SF3; TYROSINE-PROTEIN PHOSPHATASE CORKSCREW; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000035681};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 8..74
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 103..198
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 226..515
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 428..506
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 533..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 78589 MW; 33B11C7C3736B6BA CRC64;
MSQRIANFTL PNIFYNVTGK EAEKLLIKHG IEGEFLVRPS STGENAYSLS IHRGSRITHV
KLNKNELINY CIANVGYLKE HNGDIIILTR PLSWNVRKYD WNYFHPNITG LEAEKFLKEY
SKKGLFLVRQ SQSHPTDLAM SVMLGEGKVC HLKIIVVSDT YDIGGGERFP SMDRLIEHHR
KVPLIMDKGN VLRLETGLAT TKIFIPDIDM RIEQLTKTDR NGKTLLSSEF DRLQASESQR
VMYTSQKYGK KDENLDKNRY KNIVPYDLSR VKLKNEGTIE MNDYINGNYI EILSYEFPDL
ACINKHYIST QGCLPNTIND FWEMVWQEKS YIIVMVTKEI ERMKIKCTRY WPENNKVLTT
GRYNDIEVYL EEKIDMKYYI IRILEVNKYK VVNNIGDKTI KIGKRTIYHF QYIGWPDHGC
PRDPYEIVTF LKIINEYSYN KCPVDQGPMI VHCSAGIGRT GTIIVIDIIT EYIRIQGLRC
FIDILTAVKM VRAQRSGMVQ TEFQYKFVYD VVAAFIRDRT REYEMNRQKN DIKILNPTTP
NSANTISLTS SNSGSPRNNQ SQEMFSNSIS PQLSKFEFFG YNNSSNSDFQ DFISIHDDNH
RIYTSSQRSP KDLSSLESSK NVYTNSSDDR ISINQNTSSH HLPIESDNIL QGCNINIPEK
VKLQPPPLPK RKNPPNEFI
//
