ID A0A0K0EWE7_STRVS Unreviewed; 817 AA.
AC A0A0K0EWE7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0084700.1};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_0084700.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361221}.
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DR AlphaFoldDB; A0A0K0EWE7; -.
DR STRING; 75913.A0A0K0EWE7; -.
DR WBParaSite; SVE_0084700.1; SVE_0084700.1; SVE_0084700.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR11689; CHLORIDE CHANNEL PROTEIN CLC FAMILY MEMBER; 1.
DR PANTHER; PTHR11689:SF166; H(+)_CL(-) EXCHANGE TRANSPORTER 7; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 121..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 174..198
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 289..313
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 325..347
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 374..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 413..434
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 513..536
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 548..571
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 577..594
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 750..807
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 61..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 91618 MW; 63F55EA392E1F0E2 CRC64;
MSTSRWDSDA EPLIRHGMRN FRFSGRTFST SSLDPHEDPV TGLERISNSY TDLNSLNRRI
RQQHRSVRNN DPNQSTDEEE EEAISGRYES INYEMMDNKI YRNEELQPNY QTKLLWEQAN
RWFACFLIGI TTAGVAIIVD LLIHYSGQVK FRLLISHLLN LCDQKNLQGG GCMWMVLVAW
ALYNCGLVFI ASSLVIFLSP IAAGSGIPQI KCFLNGVEIP GVVKLKTIFV KVIGVACSVG
GGLAAGKEGP MIHSGGVVAA GISQGRCITF PFDFKIFEYF RNDREKRDFV SAGAAAGVAA
AFGAPIGGVL FSLEEGASFW NQALTWRMVF TAMISSFTVN MVLSIFYGQS GALSWQGLAN
FGVFKDTSYN VWEIPFFLII AVIGGLLGSL FVHLNVMLTR FRNRYLNTNF QKIVECLIVA
GASAFCGFVT LFLVDDCQPI GVNPNLTEMT KLWCSKGKYS AVANLFFQNP EENVKSLFHA
PVNSFKPTTL LIFSIEYYIL TLWTYGLSVP SGIFIPCLLT GAAWGRLFGI GVEMLFPNLT
GIDPGKYALA GAAAMLGGVV RMTISLTAII VEATKDITFG LPIMLVLMIT KWVGDFFNEG
IYDAHIELNG IPILGWEPPK LSRNKIAQEI MRADVVAVQK KEKVKRLLEI LKTTSHHGFP
VLDRIDPGLN RYDLPCYGYV EGLILRTHII IILAKKCFYK NYDCTALVDG GEKVNIGDLS
DEYSHNRIDI RRLKFTRREE ECYVNFSDIM HSSPHRVPID ASLETIFRLF RGLGLRYLLV
VDKTNKLRGI ITRKDVARFR DKRINNKYFL HERRILT
//
