ID A0A0K0EWS4_STRVS Unreviewed; 1122 AA.
AC A0A0K0EWS4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Potassium chloride cotransporter isoform b (projected from Caenorhabditis elegans ortholog kcc-2) {ECO:0000313|WBParaSite:SVE_0097800.1};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0097800.1};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_0097800.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A0K0EWS4; -.
DR STRING; 75913.A0A0K0EWS4; -.
DR WBParaSite; SVE_0097800.1; SVE_0097800.1; SVE_0097800.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 2.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR PANTHER; PTHR11827:SF73; KAZACHOC, ISOFORM G; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 3.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 4: Predicted;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 462..483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..580
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 586..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 134..302
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 419..702
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 729..848
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 860..978
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 1043..1122
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 123482 MW; AF6E0A0CC4E525AD CRC64;
MPQVDSTSEL PSNVSSTDGA PVTGGRFQVS SVDHTPKNST AVICGDSKNT NNTVILLQDK
DNGENVPLCG KNDDLALYED EYNTQGQKIG HMLRSLSLYN AVLPGSQKED DVESTGAIKH
SATVAAKMGT IIGVYLPCLQ NIFGVLFFIR LSWIVGNAGI FGAFFVVLIC CSVTFLTSIS
LSAIATNGVV PSGGPYYMIS RNLGPELGGA IGFLFYLGTT VAGSMYVTGA VEIFLLYLIP
EAKIFDDMYN NFRILGTLLL IIIGLIVLAG VKVVNKFALP CVLVVICCIF CTFIGGFVKS
NGHQDLKYCM VGDRVVNLVK ITEKIGKTPL CSPEGLKEAF CPANKSERCD AYFEVMYSSG
TNSFNNQSSI REELAIPGLF SGVFFKNFWP KYQKVGDVIT RDATRGNSGT SAEKSPYVFA
DVTTGFMMLI GVFFPSATGI MAGSNRSGNL KDASKSIPLG TLGAQLSTSF VYLSGVLLIG
GSVSDMFLRD KFGASAMGKL TIAELAVPHR LFILVGCFLS TVGAGMQSLT GAPRLLQAIA
ADDVIPFLRK FQYTDKRGEP LLAIVLTLII CECGILIAVI ENITALITQF FLMCYLGINA
ACALQSIMKA PGWRPSFRYF HWTLSSIGAA LCIAVMFISA WYFALFAIFI GAAIYKYIEY
AGAEKEWGDG LKGLALSGAR FALLNLEAKS IIHTKNWRPQ LLVLFPSSGI SAGAQPKTDD
DKIETSDCRK GLLSFVSQLK AGKGLTMVAE CIQGDFAKNY TLAETQKEII HNLMKQHKIK
GFNDVVVSKD YMEGISSLIQ TAGLGGLRHN TIVVQWPTHW SDPSNLDDSA NFVNTLRHAS
AGKCAVLVPK NVHLFPSSNE RIHGFIDVWW VVHDGGLLLL LSFLLRKNKV WKNTKIRLFT
VANVDDNTVQ MKKDLEKFLY HLRIDAQICV VEMPESDISE YVYERTLKME ERHKMIRNLQ
IKEKRVDIQS TMDDVVRERK MSRVVTDDDI VSKINIAPKH NIRGVRFSEN DEICNKEEDV
KKVTIELETS SRESPSRTNE EWSSKIIKMK NYNVRKMHNA LNLNQFMKAE SSDAQLIIVN
LPGLPELGLD TFYMEFIEAL TEGLERILLV RGSGTEVITI YS
//