ID   A0A0K0EZH3_STRVS        Unreviewed;       929 AA.
AC   A0A0K0EZH3;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Degenerin-like protein asic-1 (inferred by orthology to a C. elegans protein) {ECO:0000313|WBParaSite:SVE_0193200.1};
OS   Strongyloides venezuelensis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0193200.1};
RN   [1] {ECO:0000313|Proteomes:UP000035680}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A, De Silva N.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SVE_0193200.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC       1.A.6) family. {ECO:0000256|ARBA:ARBA00007193,
CC       ECO:0000256|RuleBase:RU000679}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A0K0EZH3; -.
DR   STRING; 75913.A0A0K0EZH3; -.
DR   WBParaSite; SVE_0193200.1; SVE_0193200.1; SVE_0193200.
DR   Proteomes; UP000035680; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR   Gene3D; 1.10.287.770; YojJ-like; 1.
DR   InterPro; IPR001873; ENaC.
DR   InterPro; IPR020903; ENaC_CS.
DR   PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR   PANTHER; PTHR11690:SF298; DEGENERIN-LIKE PROTEIN ASIC-1; 1.
DR   Pfam; PF00858; ASC; 2.
DR   PRINTS; PR01078; AMINACHANNEL.
DR   PROSITE; PS01206; ASC; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU000679};
KW   Ion transport {ECO:0000256|RuleBase:RU000679};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW   Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW   ECO:0000256|RuleBase:RU000679};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000679};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT   TRANSMEM        33..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        857..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          357..377
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..373
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   929 AA;  105193 MW;  72110493AE2C6373 CRC64;
     MYRSIILNLS DFASNTSAHG IPRAYNNKGL RRSLWLLLFL ICVGAFFGQA YYLVAKFLRN
     DKIVSVELKF EKLEFPSVTV CNLNPYKNSL ARTMGALKDT LNAFDSAISS TEKDEKSERS
     RREVPAKKLD WTKIVKSPCT KTLEETYIPI AESKEYCYCI TTGPLKSPWS CTPIKEWSMT
     TCQYCSPSDS SFCLRSSLNS TAIGILTNVT PSNIVNSTFP CICNSISTTD EECFLLNFDA
     YTPKWPLKVR EEKCKCNFDG TSSYSCQITP KNNDNNDCLC FAPQNNDNYY CKERKEWYIH
     KCKDCNWNNI CHKSWGLQTQ DKCLCDNDGK CFGIQDTSLD NYNDNVIRIN NEIINKQPKR
     IPRNKEHNNK QPPDLSPGKD VLVIYARCKC GGSISCEGQK ENANIEEYNE LCLCAYNQKN
     GIVWPCYKPE VWRDRKCIGC FGNGGCQYAN STFTKGKIAC KCADVIRFCV EIPAPSKNIN
     NVKKIASNLT GAIMSVSNHS LDLYEEEEYL DQLIGDDSIP KYWEIARTTT LPPEVIEKEI
     EKEKAFGLKE FTDPIAIRAK SAENLIFAVS NLSETEKLSL GYTHTEFIKK CSFNGRQCSV
     ENDFVKFVDP TYGNCFTFNY NKSERQNIDK AGNINGLRFE AFVNLSDYLP TTEAAGIRLT
     VHNPEQQPFP DTEGYSAPTG FLSSFGIKLK KVKRLPAPYG DCYEGEKHYD FIYKDKEYST
     EGCIRTCLQK SLVKACGCGD PRFPQYLNNS NCNINDLSSR ECLTREIKKS VSKESCNCKQ
     PCISLIYSVT YSSSRWPSGT NFKRSCAEGL TPQECLNFYR EQGAMIEVFY EQLNYEALEE
     SEAYALPNLI SDFGGQLGLF LGCSVITIME IGILIVDLIV TLFGNICRCL RKDDSEKKVN
     IYTKVVNDHN GHRNAISFVN PDNCGDKFK
//