ID   A0A0K0F914_STRVS        Unreviewed;       443 AA.
AC   A0A0K0F914;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Protein disulfide-isomerase TMX3 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:SVE_0531500.1};
OS   Strongyloides venezuelensis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0531500.1};
RN   [1] {ECO:0000313|Proteomes:UP000035680}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A, De Silva N.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SVE_0531500.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004389}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004167}.
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DR   AlphaFoldDB; A0A0K0F914; -.
DR   STRING; 75913.A0A0K0F914; -.
DR   WBParaSite; SVE_0531500.1; SVE_0531500.1; SVE_0531500.
DR   Proteomes; UP000035680; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd02981; PDI_b_family; 1.
DR   Gene3D; 3.40.30.10; Glutaredoxin; 3.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   InterPro; IPR017937; Thioredoxin_CS.
DR   InterPro; IPR013766; Thioredoxin_domain.
DR   PANTHER; PTHR46426; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   PANTHER; PTHR46426:SF1; PROTEIN DISULFIDE-ISOMERASE TMX3; 1.
DR   Pfam; PF00085; Thioredoxin; 1.
DR   Pfam; PF13848; Thioredoxin_6; 1.
DR   PRINTS; PR00421; THIOREDOXIN.
DR   SUPFAM; SSF52833; Thioredoxin-like; 1.
DR   PROSITE; PS00194; THIOREDOXIN_1; 1.
DR   PROSITE; PS51352; THIOREDOXIN_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..443
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5005329609"
FT   DOMAIN          11..125
FT                   /note="Thioredoxin"
FT                   /evidence="ECO:0000259|PROSITE:PS51352"
FT   REGION          413..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        413..431
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   443 AA;  51019 MW;  54CAE8D0E2D3706D CRC64;
     MFLHFLSFIC IVYCQQKPHS NVLELNDKFL DVKDEGMWFV AFYAPWCGHC KRLMPNWEHL
     AHAVADKEIN VRIGKIDCTR FSNVGNILKI QGYPTIIFFK NGVEIHYEGE RTNEKMLDFV
     LKSSGPVVKT INKQSDLTNI IKSSDKDPVF LFIGDESVYF GEFKEIAEKE FINVRFYKTE
     TKNILPSNIK IISEPSVIVF KDKTHNVYPN DHGKLKEWIL QEKWILIPQI SYSNLHAIGT
     SSKKLLVLVV SDFLERSKKD SKVQKFEKVA NEAALMVKKD REMASMFQFG WVDGNTIPTS
     IIIGNFDIPG ILVFNYSSYE YYLCSDDPVQ MTPKSIKTFL NSIMEGEIQQ LGGNSLVTNV
     RRSIFELCKN VYEMFVNQPI LASCLFGVPI AFFSIITYSI CSSDFSIDRD EIYSESETEE
     DELEESEEQW NLIGNDSEHE KVE
//