ID   A0A0K0FDR6_STRVS        Unreviewed;      1038 AA.
AC   A0A0K0FDR6;
DT   14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT   14-OCT-2015, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   SubName: Full=Solute carrier family 12 member 1 (inferred by orthology to a human protein) {ECO:0000313|WBParaSite:SVE_0699200.1};
OS   Strongyloides venezuelensis (Threadworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC   Strongyloides.
OX   NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0699200.1};
RN   [1] {ECO:0000313|Proteomes:UP000035680}
RP   NUCLEOTIDE SEQUENCE.
RA   Martin A.A, De Silva N.;
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|WBParaSite:SVE_0699200.1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (AUG-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A0K0FDR6; -.
DR   STRING; 75913.A0A0K0FDR6; -.
DR   WBParaSite; SVE_0699200.1; SVE_0699200.1; SVE_0699200.
DR   Proteomes; UP000035680; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR   InterPro; IPR004841; AA-permease/SLC12A_dom.
DR   InterPro; IPR018491; SLC12_C.
DR   InterPro; IPR004842; SLC12A_fam.
DR   PANTHER; PTHR11827:SF103; SODIUM CHLORIDE COTRANSPORTER 69, ISOFORM E; 1.
DR   PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR   Pfam; PF00324; AA_permease; 1.
DR   Pfam; PF03522; SLC12; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        123..143
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        244..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        269..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        321..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        351..373
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        478..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        503..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        541..574
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          122..618
FT                   /note="Amino acid permease/ SLC12A"
FT                   /evidence="ECO:0000259|Pfam:PF00324"
FT   DOMAIN          627..1037
FT                   /note="SLC12A transporter C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03522"
SQ   SEQUENCE   1038 AA;  115991 MW;  C05A753C4F1385EB CRC64;
     MGSYKESKYD NIDLNEISSR PSTITNKNIL DRGRVNPSFY SDDVSSKKSV EDFNKGHRPT
     LHELIKRVIH EDTLESNLSR VRFVFVLLII KFKFQNFTIG KVTKDGRCDK TENLQGFGWV
     KGVLMRCILC IIGATLYLRM SWIAGQAGIF LGMVVILLSL LVVLITAVSM SAIATNGEVK
     NGGCYYLISR SLGPEFGGSI GLILYIANMV KGAMNCVGLA ESIAVLLSDY GWKLIDGGIN
     DIRIYGLITC TMLQGIIFIG TEFENKTQIL LLITIILSIL SHTIGAFLPV SQDQINHGII
     GFSFKTIANN FWPDFRDGNS FITMFGIYFP AMTGIMAGAN MSGDLRDPSK SIPIGTMVAI
     IITTLIYSGT MLLSACATVR DSNGFNAPIF TNNTYNLIPP SCHESNSCKF GLANDYQVPL
     KQAVFGPFII AGIIASTLSS ASGCLIGAPR IFQALCQDRL FPGISVFGKG KGSTNEPYNA
     YFLTFFLTCG VILIGDLNAI SEIITNFFLA AFAITNFACF DSSASNSPGF RPGFKYYNEY
     LSLFGSVLCI VLMFVLSWVT SLITLFIFAI LFLYLKHSCK KINWGSSTEA NCYRVALMEL
     LKLSRQQVHI KNYRPQILVL SGNPVARQCL VDFSYAIVGG KNLLICGHVV PYYSSVSATA
     CIRKLNSKMT DLLKERNWKA FYCSISNKSL RSGVQGLLQS VGLGKMQPNI LMIGFKCNWL
     KEILDKKWRN NVFEYQGVIL DAFESNMSLC IFKNGNEKLD HSNLLGDFYE RLLNQLPEIK
     MADKDSYLQE DYLRGYTSDS SRPTSLIVQT QNLVKQRSIS SIISFGSGSR NNSTNNIASD
     VRTSTSDKFR YKIRSGIIDV WWLDDDGGLI LLIPHLLATN VYSYLNGTSI RIFVIIKNGS
     TDPKEVKENM KNLLKKFRIK YTEIKIIVEE NKELSPETES EFKFYLDLLN PKINRQNHLI
     PASLLERYSP KTRQYLQFRE LLLRYSSESS LLIIPLPIAH ESVVSSPLYM IWLDLLSKDM
     PPTLYVKGNN ISVLTYIS
//