ID A0A0K0FJH3_STRVS Unreviewed; 912 AA.
AC A0A0K0FJH3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Ionotropic glutamate receptor GLR-7 (projected from Caenorhabditis elegans ortholog glr-7) {ECO:0000313|WBParaSite:SVE_0904700.1};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0904700.1};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_0904700.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR AlphaFoldDB; A0A0K0FJH3; -.
DR STRING; 75913.A0A0K0FJH3; -.
DR WBParaSite; SVE_0904700.1; SVE_0904700.1; SVE_0904700.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd13717; PBP2_iGluR_putative; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 2.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR18966:SF411; IONOTROPIC RECEPTOR 25A; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 526..546
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 606..627
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..846
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 399..800
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 414..472
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
SQ SEQUENCE 912 AA; 104683 MW; 8AF43C8B7A0493FB CRC64;
MTVDSTFLQK TMNISYLYMK KNIPNDNITY EVVKIKNESS HEDLCKHIQP DTVFLISGVK
SNISRNIINQ VTNVTQIPLI QIESDINLLK KGKKSCSNGG CEMGNYTKSY IISVLPAVYV
FYSSLDILLP LLPFQNDVAI IYDFTINILD PNLLSLSQYI SIINVSTIEA KTTNKEVIKQ
LFILSQLYKT LLFMCQTSTI EMYAFNAEEY FTKNTFTWLA FTTDLLPFKC FDCLSVEIFW
IRIHHKISPK NFYNVRDFIN TNQLERNFSQ LLESYNYVKV STFFELFETA YKFVNVKYYE
KIISNTSSCY TARYWEKHPI KSSEFDLENY KLSDYGEYTE LENKSALIYQ DVGVRIYKIS
RKRDIQEGNI NKYLGNWTYN DGVTTFYGNF SLDVYLLKHY RIATIIQPPF TQDAKIHLND
SNNNLEGYCI DLLNNIQGDL NFNYTLYLVE DNLFGSPDEN GIWNGVVGDI VSGNADFSIA
ALAVMAEREV EIDYTIPYYD LVGTTILMKK TIVDNSLFKF LQVLEIPVWG AILGAYFLTS
ILMWIFDKLS PFSYTNLSKK EQNSELENKR KFTIKESLWF CLTSLTPQGG GETPLNISGR
FLSATWWVFG FIIIATYTAN LAAFLTVSRL EQPISSLDDL AGQYKIEYAP IKGSASETYF
KRMAGIEEKF YNIWKDMSLN ESLNSVDKSK LAIWDYPVSE KFSNLWRIMQ QSKLPNSIDE
AISRVMTSEN GFAFIGDAMD IQYAVLTNCD LQIIGNEFSR KPYALGVQTA HPMKDKLSTS
ILRLLHQRKL ESLKRKWWDE NPSKAKCPTS SDSNYGIKID NIGGVFIVIL GGIIIAIITL
VIEYIYHHRM VKNKVKLSMS NNTTDTTIHL SNIFSTSIDN TAFEDIEISE IPSSPRTTIL
HHRAVLNFNN KI
//
