ID A0A0K0FLC1_STRVS Unreviewed; 500 AA.
AC A0A0K0FLC1;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Transcription factor HNF-4 homolog (inferred by orthology to a D. melanogaster protein) {ECO:0000313|WBParaSite:SVE_0983600.1};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_0983600.1};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_0983600.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|ARBA:ARBA00005993, ECO:0000256|RuleBase:RU004334}.
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DR AlphaFoldDB; A0A0K0FLC1; -.
DR STRING; 75913.A0A0K0FLC1; -.
DR WBParaSite; SVE_0983600.1; SVE_0983600.1; SVE_0983600.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06960; NR_DBD_HNF4A; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR049636; HNF4-like_DBD.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR46587; NUCLEAR HORMONE RECEPTOR FAMILY; 1.
DR PANTHER; PTHR46587:SF8; NUCLEAR RECEPTOR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 33..108
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 229..495
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 104..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 500 AA; 58109 MW; 189B77D3663AB8B5 CRC64;
MIQNDLNLKL MKPMENSLDE IRGNFVSCDD KDSQFCVVCE DKADGIHYGI LSCRSCCAFF
RRSCVHKQKY ACRYGGKCKV TMGDRCVCRS CRYDKCLEKG MQTSMVQPKR DPTGSQKNRK
APRKTRRTFV DVGGNPSSVE SSTSENALLN SEFGVKFSND SSHQISYASS VISPISEELK
TFFKENEHCE VKHFTMSLNL NSTLGVFEKS ISNGDQQYML TRFPDHRNYT YDHFIELVRF
YQEHIRMMEL ELTPLDQIMN KGNNSTPLRE FRPEDIDPLS KAELNGLVWF IEKLDPYKYL
DNPDQQSLLQ RYSVRKLTLD HIYVASKYTE EIEKDNWVML NRAYVPPTKT GFERVTDIGT
SKAACDSRKR KFQILRPTID KILHSVVKPF NRMRINDVEI TVLHLLLMWS IRNSRFINPS
LKPVLRIQRE WAMRSLASYY ESIGHPEPYL RLGQILLLLP EIETACDMHC QDFGVAKLFD
YADMSDYWYE KLCYSSINVA
//
