ID A0A0K0FN76_STRVS Unreviewed; 2146 AA.
AC A0A0K0FN76;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=EF-hand domain-containing protein {ECO:0000313|WBParaSite:SVE_1045600.2};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_1045600.2};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_1045600.2}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 75913.A0A0K0FN76; -.
DR WBParaSite; SVE_1045600.2; SVE_1045600.2; SVE_1045600.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 182..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..416
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 583..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 616..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 782..809
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1033..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1146..1172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1228..1246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1258..1281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1293..1314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1349..1367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1444..1467
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1483..1518
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 519..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1920..1979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1996..2025
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..547
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..847
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1922..1967
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2003..2025
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 409
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 762
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1118
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2146 AA; 245404 MW; 13E9249C9000A408 CRC64;
MRNEGSNVMR SNEIRRPSYQ RITFSNDPLK DISIKQWMLP VTPAFLPPLI SPQKNSNTFR
KTDFPLPLLN SNVHLSISGN NLVPPAGEAF REMMRLAALP AISGLAAEEA RKEQSRLDGG
FGTGGHGGVG SGASPFGGIG RKPGIGTSTV KEKGPSSLFI FSEDNFIRKN AKAIIEWGPF
EYFILLTIIG NCVVLAMEQH LPKNDKKPLS EMLERTEPYF MGIFCFECLI KIIAFGFILH
KGSYLRSGWN IMDFIVVVSG VLTMLPFSPS SNETVDLRTL RAVRVLRPLK LVSGIPSLQV
VLKSILCAMA PLLQIGLLVL FAIVIFAIIG LEFYSGIFHS ACYNANGEIE NLSEKPFPCS
NKSSTTGAYN CDVPGTVCIQ QWIGPNYGIT SFDNIAFAMI TVFQCITMEG WTSVMYYTND
SLGSTYNWAY FIPLIVLGSF FMLNLVLGVL SGEFAKERER VENRREFLKL RRQQQIEREL
NGYLEWILTA EEVILKEDRT TEEEKAAIME ARRRAATKKI KQATKQQSTE TEEELEEEEE
EEDEESYIED QGGKKMKRSF LDNVNRKIRN IRTSLRIIVK SQIFYWSVIT LVFLNTVCVA
SEHYGQPAWF TEFLKYAEYG FLGIFICEML VKLFAMGYRT YFASKFNRFD CIVIVGSAFE
VLWAELKGGS FGISVLRALR LLRIFKLTSY WVSLRNLVRS LMNSMRSIIS LLFLLFLFIV
IFALLGMQLF GGKFNFPNMH PYTHFDTFPI ALITVFQILT GEDWNEVMYL AIESQGGIYD
GGMVYCIYFI VLVLFGNYTL LNVFLAIAVD NLANAQELTA AEEADEKANE ICDDSEDGED
ENGDQCIDMD EKDYYDDECE EEESPFGGPK PIVPYSSMFI FSHTNCLRVF VHSFVSTKYF
EMFVMFVICL SSIALSAEDP VDEENPRNKV LQYMDYCFTG VFACEMLLKL IDQGVILHRG
SYCRDFWNVL DGVVVVCALV AFSFAGTDGA AGKNLNTIKS LRVLRVLRPL KTIKRIPKLK
AVFDCVVNSL KNVFNILIVY FLFQFIFAVI AVQLFKGTFF YCTDSNKKFA HECHGQFYIY
SRQDDEPIVQ PREWKLRPFN YDNTLNAMLT LFVVTTGEGW PGIRQNSMDT TEEDQGPSPF
FRVEMALFYV MFFIVFPFFF VNIFVALIII TFQEQGEAEL SEGDLDKNQK QCIDFALNAR
PRSLFMPENK NSMKYRIWRL VTSTPFEYFI MAMICCNTLI LMMKFHGNSP GYEKVLRFFN
TALTAVFTVE SILKILAFGV RNYFKDGWNR FDFITVVGSI TDALVTEFGG HFVSLGFLRL
FRAARLIRLL QQGYTIRILL WTFVQSFKAL PYVCLLIGML FFIYAIVGMQ VFGNIRLDST
TEINRHNNFQ SFFNSVILLF RCATGEAWQD IMLSCTAGKY CASKDEFTEY NIMKGATCGT
NMSYAYFTSF VFLSSFLMLN LFVAVIMDNF DYLTRDSSIL GPHHLDEFIR VWADYDPAAT
GRIHYTDMYE MLRNIAPPVG FGRKCPYRLA YKHLIRMNMP VSEDGTVHFT TTLFALIRES
LSIKMRPVEE MDEADEELRQ TLRKIWPLKA KKNMIDLVVP PNHELCYQKL TVGKIYAGLL
ILENYRARKT GTEIERQRKA REAMKLLGRT QAVIELPTKR IVQEKLFGNT NKVRPAILVQ
QPTLPDGELG DSIYVDTGHE ICSGGLFGGG LRGLVAAAKS AAGGGGASGN QSTIHHREHL
DDYDDDEVSI QNNDNNKYMQ NDIHSNYNND EDVGINSNTH VNNQRPQQSL FSTLVDTIKS
TKSNDSIISN THDYQQKMGQ KPKNDNNDLY YDDSHTSLDN YIQTYDREPM RYGNNYNNGK
FSGVFNRIRR RDTRSDYQPV GIQHYFPRSQ KYMPRYCGSS QNNYYSNKRD DYYDETQHLL
SNQRHSRSPS PQDVHPNPSL YGRSYSERYS GYQPIRNPPT MSYSEDHAET YNRYPGNKNK
VHDNYSMSYY GESHVPKPGV FHNSPNVPNT TNRSLRHQPM GYSNPPNQKY DDIYSDINYP
NNKNIHNTGS AQNIRVNWRY DDQYDEDPRI VPTQQRRLPD INKISMPRPR SGFIEPSNYE
NTNNFPRYQP QYHSQSGAQT VVYAQPGNVP LSDSEGEEGR ERWAMI
//