ID A0A0K0FWY0_STRVS Unreviewed; 426 AA.
AC A0A0K0FWY0;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 22-FEB-2023, entry version 32.
DE SubName: Full=Rho guanine nucleotide exchange factor 3 (inferred by orthology to a D. melanogaster protein) {ECO:0000313|WBParaSite:SVE_1694200.1};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_1694200.1};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_1694200.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
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DR AlphaFoldDB; A0A0K0FWY0; -.
DR STRING; 75913.A0A0K0FWY0; -.
DR WBParaSite; SVE_1694200.1; SVE_1694200.1; SVE_1694200.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45834:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L; 1.
DR PANTHER; PTHR45834; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..62
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 85..269
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 300..408
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 426 AA; 49395 MW; 05B255300F6FA1BF CRC64;
MQAEAVWDHV ALQPDELPFN VGDLITVLDC NPTLPGHNGF WYGISQNRTG WFPSSYVRVK
NGTESLKFID CVNDQDDFPQ SMRYQRRKII EELLKTEKDY VKLLQNIVFG FLDQCRRRTE
MFSKERISKI FGNIEQICLL HCKLLKDLES CIDHKQPENS CISKAFLRNC RNFTIYSEYC
SNRPVSCAEL VSLEQNKQYH QFFEACRLLR GMCNLPLEGF LLTPVQRICR YPLQLLELIK
STPGSHPDNE NLEKAHKTMR AVASHINDSQ KRIDGIQKII MWQRNVIGFR GPDLIENNQK
MMKSGELQCR AVHKNSIQWN KTVNVFLFDQ SIVICKKDVL KKGALIFKER MSMQNIIVQD
LNDGKDSVLG CNLKNAFKLS SPNREYYFTS SDGEAKRQWL EAIHSRPDPM PPSNTERRLA
LVSLVY
//
