ID A0A0K0FZ54_STRVS Unreviewed; 1081 AA.
AC A0A0K0FZ54;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=adenylate cyclase {ECO:0000256|ARBA:ARBA00012201};
DE EC=4.6.1.1 {ECO:0000256|ARBA:ARBA00012201};
OS Strongyloides venezuelensis (Threadworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Tylenchina; Panagrolaimomorpha; Strongyloidoidea; Strongyloididae;
OC Strongyloides.
OX NCBI_TaxID=75913 {ECO:0000313|Proteomes:UP000035680, ECO:0000313|WBParaSite:SVE_1773100.1};
RN [1] {ECO:0000313|Proteomes:UP000035680}
RP NUCLEOTIDE SEQUENCE.
RA Martin A.A, De Silva N.;
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|WBParaSite:SVE_1773100.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (AUG-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP = 3',5'-cyclic AMP + diphosphate; Xref=Rhea:RHEA:15389,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58165; EC=4.6.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001593};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; A0A0K0FZ54; -.
DR STRING; 75913.A0A0K0FZ54; -.
DR WBParaSite; SVE_1773100.1; SVE_1773100.1; SVE_1773100.
DR Proteomes; UP000035680; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016849; F:phosphorus-oxygen lyase activity; IEA:InterPro.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45627; ADENYLATE CYCLASE TYPE 1; 1.
DR PANTHER; PTHR45627:SF23; AT30656P-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW cAMP biosynthesis {ECO:0000256|ARBA:ARBA00022998};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000035680};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 30..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..660
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 666..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 696..717
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 729..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 333..460
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 877..1015
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 1081 AA; 124031 MW; C3E1D8D4DFED973D CRC64;
MEEYKTKNRE VRGVLLRHWT GLDRARLHTF HLWLIMYSLS LIFLTAYFAY SPLTFQFVII
GMTFIISLII SYCLIRCEKE VSDNYITKNK NLSFKLSINN TRKHYLIISL LSMIGFPLFI
WLIYLPCILN RDELKKDVKD FQIPSIFSSF ILLILYQFFI MPRNRRTFFF ITIIFVILNI
LYMNLLNFNE GGSFGQDTVY SNKTYFLRFY SPFQSNETNL NDTNNKDSKF SKNWIILFLQ
LLMVIVGLMY DSKSSGSRCS IERKITEAVT RRTELETLKD RQEQLLLSVI PAYLADKVSK
SMREISSGNN VNKGKQHHKL FHDLHVQSHD NVSILFADIV NFTVLAKQLT AKDLVRTLNE
LYSKFDEDAQ KLQCMRIKFL GDCYYCVSGM PVNRPNHADM CVLMGLEMIK TIKQVRDATG
VDVNMRIGVH TGNIYCGIIG IIRWQFDVWS DDVTLANQME SSGRPGAVHI TKKTKEMLIG
DYRIMSASED IDNERKNSKN KEETYYILPD KNTILERTAS IFRNKRKNLD LISNEDINNS
QGRLSIKSKF SKITEFWGAE TPFANLNRIN NNEGSLNRRP NYSNTIQCMT LIENNLNKIN
FSNVKSIINW NSKRTEYQTA KMLFPFFKNP LNINLSECSS LLILSIPLAI ANFCTIFAYY
PPDYHPLLVG QLCVCLLGLA MICIIEQLTV VGHSFLTSLA FSVSLLIAIG SHITITFRSV
VDDATKIPSL IWLPSAICHL CSIPILYRLS YAFRCVLATA DLCIFFVLLV VFPGYGINYM
LKTVNYKILS SQITAITIHL LAVYLLLLFV EWITEYEHKI EAACDMAFKN EETEVQMMQD
INTLLIHNIL PQSVAVKFLE PDRQIDELYA KDHNNVCVMF ASIPNFNDYW SECEKSRKLE
CLRLLNEIVC EFDKLLLKPK FSCIEKIKTV ANTYMAASGL YEPEGEFTRQ RNVINMVEFA
LAMNGVLEQL NLDSFQNFTL RIGMSLGPLV GGVIGAQKPQ FDIWGNTVNM ASRMDSHGIV
NKIHITKEVA EILMKEGYEI ESCGAIKVKG VKDPMETFAL CLDCRRTSNS SCQIGNKKSA
F
//
