ID A0A0K0IYY7_BRUMA Unreviewed; 170 AA.
AC A0A0K0IYY7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Protein Dr1 {ECO:0000256|ARBA:ARBA00018742};
DE AltName: Full=Down-regulator of transcription 1 {ECO:0000256|ARBA:ARBA00032651};
DE AltName: Full=Negative cofactor 2-beta {ECO:0000256|ARBA:ARBA00030451};
GN Name=bma-dro-1 {ECO:0000313|WormBase:Bm13777};
GN Synonyms=Bma-dro-1 {ECO:0000313|EMBL:CTP81190.1,
GN ECO:0000313|WBParaSite:Bm13777.1};
GN ORFNames=Bm13777 {ECO:0000313|WormBase:Bm13777}, BM_Bm13777
GN {ECO:0000313|EMBL:CTP81190.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CTP81190.1};
RN [1] {ECO:0000313|EMBL:CTP81190.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP81190.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CTP81190.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CTP81190.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm13777.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SIMILARITY: Belongs to the NC2 beta/DR1 family.
CC {ECO:0000256|ARBA:ARBA00009245}.
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DR EMBL; LN856924; CTP81190.1; -; Genomic_DNA.
DR RefSeq; XP_001898040.1; XM_001898005.1.
DR STRING; 6279.A0A0K0IYY7; -.
DR EnsemblMetazoa; Bm13777.1; Bm13777.1; WBGene00234038.
DR GeneID; 6101484; -.
DR KEGG; bmy:BM_BM13777; -.
DR WBParaSite; Bm13777.1; Bm13777.1; WBGene00234038.
DR CTD; 6101484; -.
DR WormBase; Bm13777; BM18368; WBGene00234038; Bma-dro-1.
DR OMA; EVCNQSN; -.
DR OrthoDB; 297906at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0017054; C:negative cofactor 2 complex; IEA:InterPro.
DR GO; GO:0140223; F:general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR042225; Ncb2.
DR PANTHER; PTHR46138; PROTEIN DR1; 1.
DR PANTHER; PTHR46138:SF1; PROTEIN DR1; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 10..72
FT /note="Transcription factor CBF/NF-Y/archaeal histone"
FT /evidence="ECO:0000259|Pfam:PF00808"
FT REGION 144..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 170 AA; 19596 MW; 9FE0561D974E40D7 CRC64;
MGDEDNEVGL PQKGLNMIIK DVIPEMRVAN ESRELLNACC VEFVRHISRE AQRISADDQR
KTIYHEHVQK ALINLAFPYD YVEAADSVLS ECKIAAENKL KRKNSRLDKC GIPEDQLYLM
QQELIEKARQ EQLEAEAAEM NRLQQENRGL QRSLSELLSK DEDDEDYDTA
//
