ID A0A0K0J6Z3_BRUMA Unreviewed; 280 AA.
AC A0A0K0J6Z3;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=BMA-MLS-2 {ECO:0000313|EMBL:CDP94549.1};
DE SubName: Full=Homeobox domain-containing protein {ECO:0000313|WBParaSite:Bm2671.1};
GN Name=bma-mls-2 {ECO:0000313|WormBase:Bm2671};
GN Synonyms=Bma-mls-2 {ECO:0000313|EMBL:CDP94549.1,
GN ECO:0000313|WBParaSite:Bm2671.1};
GN ORFNames=Bm2671 {ECO:0000313|WormBase:Bm2671}, BM_Bm2671
GN {ECO:0000313|EMBL:CDP94549.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm2671.1};
RN [1] {ECO:0000313|EMBL:CDP94549.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP94549.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP94549.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP94549.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm2671.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the HMX homeobox family.
CC {ECO:0000256|ARBA:ARBA00038165}.
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DR EMBL; LN856931; CDP94549.1; -; Genomic_DNA.
DR RefSeq; XP_001899257.1; XM_001899222.1.
DR STRING; 6279.A0A0K0J6Z3; -.
DR EnsemblMetazoa; Bm2671.1; Bm2671.1; WBGene00222932.
DR GeneID; 6102688; -.
DR KEGG; bmy:BM_BM2671; -.
DR WBParaSite; Bm2671.1; Bm2671.1; WBGene00222932.
DR CTD; 6102688; -.
DR WormBase; Bm2671; BM19386; WBGene00222932; Bma-mls-2.
DR OMA; HASADFN; -.
DR OrthoDB; 2881967at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR46110; HOMEOBOX PROTEIN HMX; 1.
DR PANTHER; PTHR46110:SF3; HOMEOBOX PROTEIN HMX; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 105..165
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 107..166
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 23..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..80
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 30597 MW; 7723DFB95A70DEC2 CRC64;
MFSSFIHASA DFNSYLCFPK QQSKVIDNSK TVTDPVSEVG SDCDDDDNVD DDDDNDDDDN
DDDDDDDDDD DDDDGAGNGD DNDGDIAIRA SDDESTVLLS GSTIPRKKKT RTVFSRQQVS
RLEMTFDMKR YLSSQERAYL ASTLHLSETQ VKIWFQNRRN KWKRQAASEV DSSSAMNIHR
SHIFASNMHH ISDASERFSG NLAVANSIPI TPLANIAPSL IHPAILFHSN PTATSVSTTS
APPQAIINFS SAENVAAAAK LFYGTYDSSG TGITGHNALT
//
