ID A0A0K0JAL1_BRUMA Unreviewed; 720 AA.
AC A0A0K0JAL1; A0A0J9XVV4;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=One cut domain family member {ECO:0000256|RuleBase:RU361129};
GN Name=bma-ceh-38 {ECO:0000313|WormBase:Bm3512b};
GN Synonyms=Bm1_43870 {ECO:0000313|WBParaSite:Bm3512c.1}, Bma-ceh-38
GN {ECO:0000313|EMBL:CDP96828.1};
GN ORFNames=Bm3512 {ECO:0000313|WormBase:Bm3512b}, BM_Bm3512
GN {ECO:0000313|EMBL:CDP96828.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP96828.1};
RN [1] {ECO:0000313|EMBL:CDP96828.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP96828.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP96828.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP96828.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm3512c.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the CUT homeobox family.
CC {ECO:0000256|ARBA:ARBA00008190, ECO:0000256|RuleBase:RU361129}.
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DR EMBL; LN856962; CDP96828.1; -; Genomic_DNA.
DR RefSeq; XP_001900236.1; XM_001900201.1.
DR AlphaFoldDB; A0A0K0JAL1; -.
DR EnsemblMetazoa; Bm3512c.1; Bm3512c.1; WBGene00223773.
DR GeneID; 6103658; -.
DR KEGG; bmy:BM_BM3512; -.
DR WBParaSite; Bm3512c.1; Bm3512c.1; WBGene00223773.
DR CTD; 6103658; -.
DR WormBase; Bm3512b; BM28466; WBGene00223773; Bma-ceh-38.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR003350; CUT_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR PANTHER; PTHR14057:SF50; HOMEOBOX PROTEIN CEH-38; 1.
DR PANTHER; PTHR14057; TRANSCRIPTION FACTOR ONECUT; 1.
DR Pfam; PF02376; CUT; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM01109; CUT; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR PROSITE; PS51042; CUT; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
KW ECO:0000256|RuleBase:RU000682};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Transcription {ECO:0000256|RuleBase:RU361129};
KW Transcription regulation {ECO:0000256|RuleBase:RU361129}.
FT DOMAIN 320..406
FT /note="CUT"
FT /evidence="ECO:0000259|PROSITE:PS51042"
FT DOMAIN 440..500
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 442..501
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 34..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 104..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 410..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 497..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 512..526
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 720 AA; 79640 MW; E8F3335F68B8C52D CRC64;
MERAASTAPP TTYQLQIDPN ITFNSVNRPF EELPENFLES ISPQQNQSSA PQESPQLAPL
APMSLGSNDN FGKSSDFNAY ATLAPMSATP SYVGTMKIEP LQDQLHSTSM QHSSHSSGLD
KLSSGPAGLL SPLQTTARPD SLVCSSLLSA HQNGGRASEM LAGLRRHHPY IKEEVDLGQD
FKTMDSSFMS HQPQQSANLL GQDDHQQELD HRLANAETPP AVSNVELASS FIATMIGEQP
PSSPAPQHTI FRQSRRNFSS VDTTELRSSE DLEVNAAETS GDDLTFADDN GEPTSTTRLT
STVGAPRASY STKDATDPLN AEIDDDIYID TTDLCKRIAW ELKQHSIPQA IFAERILCRS
QGTLSDLLRN PKPWNKLKSG RETFRRMFNW VQQPLELRLG ILDMYKGKGG MLPSSMSPPT
PAQNARQGSR HKGRDGDGLS STKRPRLVFT DIQKRTLQAI FKETQRPSRE MQQTIAEHLQ
LDLSTVANFF MNARRRSRSG PLMGDAPAPY QQIRPITPPP ESPPQHRNPN KARGNRHISR
SDGENSSVTS SSRIETTVAQ VVEEAAEYAR RYDEGTYSDE KNLKFRIGEI DSSVGIEDNN
SRIDYEDQAP EYKMIRLSND HSLSIDSRQI ATADELLASE LPDDEAQLNP DPNTSMQAVK
TVNDKDESVF LVSVPVTAES ECDTVEQQRL HPVMSFGNKM IIVKVEQREN PTSNAAANSH
//
