ID A0A0K0JED5_BRUMA Unreviewed; 1229 AA.
AC A0A0K0JED5;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Abnormal embryonic partitioning of cytoplasm protein 3, isoform b, putative {ECO:0000313|WBParaSite:Bm4375a.1};
DE SubName: Full=Bm4375, isoform b {ECO:0000313|EMBL:CDQ00221.2};
GN Name=bma-par-3 {ECO:0000313|WormBase:Bm4375b};
GN ORFNames=Bm4375 {ECO:0000313|EMBL:CDQ00221.2,
GN ECO:0000313|WormBase:Bm4375b}, BM_Bm4375
GN {ECO:0000313|EMBL:CDQ00221.2};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDQ00221.2};
RN [1] {ECO:0000313|EMBL:CDQ00221.2, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ00221.2,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDQ00221.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDQ00221.2};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm4375a.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR EMBL; LN857013; CDQ00221.2; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K0JED5; -.
DR EnsemblMetazoa; Bm4375a.1; Bm4375a.1; WBGene00224636.
DR WBParaSite; Bm4375a.1; Bm4375a.1; WBGene00224636.
DR WormBase; Bm4375b; BM48452; WBGene00224636; Bma-par-3.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF17; BAZOOKA, ISOFORM B; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 2.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 286..362
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 418..487
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 545..612
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 651..751
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 844..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 898..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..673
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..688
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 913..933
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 964..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 136092 MW; 3B5747739289313E CRC64;
MKAKVTVRFG KVGVVVPCYD YMTVNDLIKA SVLRYKKATG RVNNATTVGS TGIVHCQQNA
NYVTILAIYD EPSFAVVDSA STNASRFATN GTISLTSSLA TAKTVASAES PLDGKLNIIS
SSSDGDIVEI TSIAIPPTDG LRVISDNAHT LQQKPSSSSV ITSPESVSSQ CLPSTQFDQK
HNDMSNTCRV YHSALKNSGS PRSKYRVTIS PDVDCQPSQE SPIFTKESLM TRTSARKSRL
TDNFFDAKER LEEKLADGIN SRVVKGDMKS PKLIPLMEAA NRGQTVIILS DSTINMKLGI
EISPVYDPSN DMRLQAVEIR QIDDEGRVSS DGRLRIGDRI VEINQRPVYQ MSISRARAYL
HEIQAIAHPS LTIDRSIETF ASDTISHHSQ SSTSSLQKRP ILSALQQANT TALGITFPVE
IVKRRGGFGF TVTSRETAKG ERLFYIGTVK AGGAAVNKLR AGDRLLQING RKTAEFTQSD
MVKRLKKLDV GDSINLLVSR IGSQENENQN PLVVTNNYNS DSEHYHQERA SEGTERYGEE
ILTLKIALNE TGSAGLGVSL KARAVMKPDG TRHDCGIFIK KVLHGGAAYK DGRLRLNDQL
IGIEDTDLRR MTRNSEASDA ITRCLKNLGP NANDVCLRVA RKVELNHSNA FPSVRSSTDE
SWTPNCESSK IYDRSQTKSA DDDNATAKKQ ETPNGYNADV PRFSSSDDRP LNANGDFDST
ASDRQKYLSE DEISRTGGSG FNRENPARRS ISEKRHMGVG MDANSTMLFQ KIKHNRQMSA
PLLHRFVPFI SPTHKSLAMF SSRSAVSLRE KCRRRSLVSL QSSEEKTVSG RSIEKREQRI
PISASYVSST NNESTNVASS SSSPNRRSLS LESMDTHQSP ALAIVSAHSN GPAIRDTRIE
QTAKRGHPST LKRSQKSRCN GYIKPSISDA EDQTSAGKGR DESYASLPRE ISATSKEKQQ
RRKSVGGSIF SKITQRFGGS RSRDTSPEKA VSFDIAESKS SRDKSNRTQD DREWSKESRS
NQSIRKAPPP YKPSSYDILQ STDPTCYVNG KGVLEWRGQY QTAVRNNEYN CGKGRNSSVN
RQTRNGCGDE LYAHLRQQQR QQYANHPQCC YERRREQQQQ RVAYYTGYST DYYDAFNAWF
AYSSATACRN IPIITRGRSG YPSQHTYFSA AAETVSSSRA AVQQIHHQRF RSCPIQFSSS
GMRTKQSIER TGPYYATGYD LHSGRISDF
//
