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Database: UniProt
Entry: A0A0K0JJ21_BRUMA
LinkDB: A0A0K0JJ21_BRUMA
Original site: A0A0K0JJ21_BRUMA 
ID   A0A0K0JJ21_BRUMA        Unreviewed;       986 AA.
AC   A0A0K0JJ21;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   16-JAN-2019, entry version 20.
DE   SubName: Full=Bm5473 {ECO:0000313|WBParaSite:Bm5473};
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm5473};
RN   [1] {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm5473}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=FR3 {ECO:0000313|Proteomes:UP000006672,
RC   ECO:0000313|WBParaSite:Bm5473};
RX   PubMed=17885136; DOI=10.1126/science.1145406;
RA   Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J.,
RA   Allen J.E., Delcher A.L., Guiliano D.B., Miranda-Saavedra D.,
RA   Angiuoli S.V., Creasy T., Amedeo P., Haas B., El-Sayed N.M.,
RA   Wortman J.R., Feldblyum T., Tallon L., Schatz M., Shumway M., Koo H.,
RA   Salzberg S.L., Schobel S., Pertea M., Pop M., White O., Barton G.J.,
RA   Carlow C.K., Crawford M.J., Daub J., Dimmic M.W., Estes C.F.,
RA   Foster J.M., Ganatra M., Gregory W.F., Johnson N.M., Jin J.,
RA   Komuniecki R., Korf I., Kumar S., Laney S., Li B.W., Li W.,
RA   Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA   McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA   Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA   Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA   Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA   Blaxter M.L., Scott A.L.;
RT   "Draft genome of the filarial nematode parasite Brugia malayi.";
RL   Science 317:1756-1760(2007).
RN   [2] {ECO:0000313|WBParaSite:Bm5473}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (SEP-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00500}.
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DR   WBParaSite; Bm5473; Bm5473; WBGene00225734.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0006801; P:superoxide metabolic process; IEA:InterPro.
DR   CDD; cd00191; TY; 1.
DR   Gene3D; 2.60.40.200; -; 1.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   InterPro; IPR000716; Thyroglobulin_1.
DR   InterPro; IPR036857; Thyroglobulin_1_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR008197; WAP_dom.
DR   Pfam; PF00080; Sod_Cu; 1.
DR   Pfam; PF01826; TIL; 5.
DR   Pfam; PF00095; WAP; 1.
DR   SMART; SM00211; TY; 1.
DR   SUPFAM; SSF49329; SSF49329; 1.
DR   SUPFAM; SSF57567; SSF57567; 5.
DR   SUPFAM; SSF57610; SSF57610; 1.
DR   PROSITE; PS51162; THYROGLOBULIN_1_2; 1.
DR   PROSITE; PS51390; WAP; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000006672};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00500,
KW   ECO:0000256|SAAS:SAAS00485231};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    986       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5017451002.
FT   DOMAIN       94    137       WAP. {ECO:0000259|PROSITE:PS51390}.
FT   DOMAIN      130    200       Thyroglobulin type-1.
FT                                {ECO:0000259|PROSITE:PS51162}.
FT   DOMAIN      264    311       WAP. {ECO:0000259|PROSITE:PS51390}.
FT   DOMAIN      720    774       WAP. {ECO:0000259|PROSITE:PS51390}.
SQ   SEQUENCE   986 AA;  108054 MW;  C68FD0B7CE8AA3CD CRC64;
     MTNCAKIVSF LAILFANSIR TQRFRRICEA QETCMNCGDD RFSYYKCNAS HDCLADEICT
     GQGFCCPATE LSRTVSSLFS DNFEFIGVPA YKYESEKSGM CPDGSPWSRQ CSNDSDCTLT
     NEICATGKCC SVCSQHRRRV LNDLPTNNVV GVHIPQCDPA GKHYRAVQCR TGTEECWCVS
     RFGRIIGSLK PKTTNLNAAC ETLRLTVKRI IEEKRETVNV RRKQGSLTSS KEKSHSIDII
     VKGQSSELKE QLRSINGIVS DKCLWMKPGH CSDQPVSLTD ASKLCHCDDD CPALQKCCPV
     LTSGLACSSN ITVNTDKFPV ISHFPLTNST TTTTTICAKN EQFVECLDEC KATCFTKTTI
     PCFIERCKSG CQCKSGFIRQ KNDLHAPCIP QDECPPQSIM ESKTRCADPL REYEICGPGC
     PISCSSRSEK CKVEGCVEGC FCKIPYILEN GADPIHSRCI LPAYCPLLVR DYSPPRNATV
     VHFTSTSPVT SNSRLFLEGR EDSITPPTAM HCSDPFKNFH ICGSGCPAGC NNKVAGFCGT
     QCVAGCFCRN PYILQDAYNL NSPCILPHQC HSLTVQQQIC SDPRKQWTHC FSSQCTRSCS
     NLETSCKSSE CTPGCICREP YVLLDSRNPN SRCVLPSECG SQCSDPLKEY QACASSCPIG
     CNNRVPQTCS PCVSGCFCKS GFVFEDAINW RTSECIPLNQ CPVGNISAIS GIFNPENNKL
     ANMAMAECPE TTVDLSGKFC NFDSDCPIQQ RCCRSNLFAM ISSKRSRCTC IDPHAYWDSC
     GILCPEYCGQ LATPVCSSTC NPGCHCASGY VKARNHVMAP CVLRTQCSQQ GKYYSTAENR
     EGTTKPYNLY KEIASAKMLS DGNKIIGDVK IKQINKGRIK LEGTIEGLPD GEHAIIIHQA
     GDLSNSCANI GPIMASDKKF NVSAIFGNVK ANGTADVTID REIDWPQDIS LIGHSLVIHK
     LSVIEWSLRD KDILPLACGT IGFASA
//
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