ID A0A0K0JPD9_BRUMA Unreviewed; 526 AA.
AC A0A0K0JPD9; A0A0J9XR22;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 3.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Bm6726 {ECO:0000313|EMBL:CDP93901.1, ECO:0000313|WBParaSite:Bm6726.1};
GN ORFNames=Bm6726 {ECO:0000313|EMBL:CDP93901.1,
GN ECO:0000313|WormBase:Bm6726}, BM_Bm6726 {ECO:0000313|EMBL:CDP93901.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP93901.1};
RN [1] {ECO:0000313|EMBL:CDP93901.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93901.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP93901.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP93901.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm6726.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2022) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-
CC [histone]; Xref=Rhea:RHEA:58196, Rhea:RHEA-COMP:9845, Rhea:RHEA-
CC COMP:11338, ChEBI:CHEBI:15377, ChEBI:CHEBI:29969, ChEBI:CHEBI:30089,
CC ChEBI:CHEBI:61930; EC=3.5.1.98;
CC Evidence={ECO:0000256|ARBA:ARBA00001028};
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DR EMBL; LN856913; CDP93901.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K0JPD9; -.
DR EnsemblMetazoa; Bm6726.1; Bm6726.1; WBGene00226987.
DR WBParaSite; Bm6726.1; Bm6726.1; WBGene00226987.
DR WormBase; Bm6726; BM27008; WBGene00226987; -.
DR OMA; PAGYYWM; -.
DR OrthoDB; 124800at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.800.20; Histone deacetylase domain; 1.
DR InterPro; IPR000286; His_deacetylse.
DR InterPro; IPR023801; His_deacetylse_dom.
DR InterPro; IPR037138; His_deacetylse_dom_sf.
DR InterPro; IPR023696; Ureohydrolase_dom_sf.
DR PANTHER; PTHR10625:SF4; HISTONE DEACETYLASE 6, ISOFORM G; 1.
DR PANTHER; PTHR10625; HISTONE DEACETYLASE HDAC1-RELATED; 1.
DR Pfam; PF00850; Hist_deacetyl; 1.
DR PRINTS; PR01270; HDASUPER.
DR SUPFAM; SSF52768; Arginase/deacetylase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672}.
FT DOMAIN 24..316
FT /note="Histone deacetylase"
FT /evidence="ECO:0000259|Pfam:PF00850"
SQ SEQUENCE 526 AA; 59722 MW; 9E0CEA412E7D7705 CRC64;
MKQRKVYIGT DRAMLQHRCE WDYHLEHPER LSAVLEKLES SGLLNRCIHL KPKKANLEDL
CLVHSRTYVE RIAQTRNMDL EELEKIASTF DDVYFNNYSY EAAAISVGIS LQAMEAVLFD
GERKSSSFAI IRPPGHHASR ERACGFCIFN NVAICARTLG VEKVLIVDWD VHAGQGTQYA
VEDDPKIKLI SIHRYQHGLF WPHLPESAIS HGYKNTINVP LNGVGMGDSE YIAFVQHFVV
PIIYDFVPSL ILISSGFDAG FGDEEGNMNV SPAGYYWMTK LILDAATTVG SPLCMLMEGG
YFIDSLAYGV QFCIKALLND PEPHIEVGLC SHVFLHSLHS AVLFHASEFP RLQLLADVTS
HIRVRSLVPA ITPIKTEYKY QKVSDGQDDI YPTRGIYVRP AESLIERLQQ ELQEIISNSY
STKNKEAISL VFTQKINEEN TEKEIQIEVK DLEHSAVVDF IQLHVLNTPC IKLILSEKNR
MDQLKYTQNN CSEDTVISIV ESLFKLFNHQ HCINFKHLLD FELDLT
//
