ID A0A0K0JQP7_BRUMA Unreviewed; 517 AA.
AC A0A0K0JQP7;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Bm7048 {ECO:0000313|EMBL:CRZ22007.1};
DE SubName: Full=Sodium Bile acid symporter family protein {ECO:0000313|WBParaSite:Bm7048.1};
GN ORFNames=Bm7048 {ECO:0000313|EMBL:CRZ22007.1,
GN ECO:0000313|WBParaSite:Bm7048.1, ECO:0000313|WormBase:Bm7048},
GN BM_Bm7048 {ECO:0000313|EMBL:CRZ22007.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|Proteomes:UP000006672, ECO:0000313|WBParaSite:Bm7048.1};
RN [1] {ECO:0000313|EMBL:CRZ22007.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22007.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CRZ22007.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CRZ22007.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm7048.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
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DR EMBL; LN855353; CRZ22007.1; -; Genomic_DNA.
DR STRING; 6279.A0A0K0JQP7; -.
DR EnsemblMetazoa; Bm7048.1; Bm7048.1; WBGene00227309.
DR WBParaSite; Bm7048.1; Bm7048.1; WBGene00227309.
DR WormBase; Bm7048; BM34925; WBGene00227309; -.
DR OMA; IGFCTQF; -.
DR OrthoDB; 2961577at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361:SF28; RH04535P; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Signal {ECO:0000256|SAM:SignalP}; Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022847}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..517
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5013455967"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 240..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 437..460
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 496..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57579 MW; 79B30C80DB8F9CCA CRC64;
MTSRGCPFFL LIRLILNMMV SVTSSGIQSV ARIRFDPPYI HDLMAGTNKT VKVTVDLDTN
RQEFAKLPPK KSFAVFLKSI DEDIATAAKE RKQFKLGEYS SKRNNSETYE VNITLTGHFL
GKTAVKVRLL SMDETMDDDR FLYEISESGN DFGQQDNMLD VWVIQDNKRL ENRLFLSALV
ILIIIANILM GCELDGRVML EVIKEPVAPM IGFCTQFIAM PLLAWGIANI IFTANGLHSF
ALGLFVTGCV PGGGASNYWT VLLDGNLPVS LTMTFCSTIA ALVMIPFWMW LLGFHFLDSF
HPEAIIKIPY IKILSSLVIM IVPLIFGVAI SHFKPTLRLQ ARKIMRPFII FVLIFLIGFG
ALANIYMIRL LTWTAVIGSL LLPWCGFAIG CLTAVILRQS PPNVTSIAIE TGIQNTGIAI
MLIKFSFPDP DADISALIPV ICASMTPVPL LFIVAIHWLC KKLEMRRNAK SSHIEEIAVK
INPGIDNSNG TPIIKYKSNP NDDSPLMNIN EKRNISR
//
