ID A0A0K0JZZ2_BRUMA Unreviewed; 345 AA.
AC A0A0K0JZZ2;
DT 14-OCT-2015, integrated into UniProtKB/TrEMBL.
DT 14-OCT-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Bm9636 {ECO:0000313|EMBL:CDP94826.1};
DE SubName: Full=MPN domain-containing protein {ECO:0000313|WBParaSite:Bm9636.1};
GN ORFNames=Bm9636 {ECO:0000313|EMBL:CDP94826.1,
GN ECO:0000313|WBParaSite:Bm9636.1, ECO:0000313|WormBase:Bm9636},
GN BM_Bm9636 {ECO:0000313|EMBL:CDP94826.1};
OS Brugia malayi (Filarial nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=6279 {ECO:0000313|EMBL:CDP94826.1};
RN [1] {ECO:0000313|EMBL:CDP94826.1, ECO:0000313|Proteomes:UP000006672}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP94826.1,
RC ECO:0000313|Proteomes:UP000006672};
RX PubMed=17885136; DOI=10.1126/science.1145406;
RA Ghedin E., Wang S., Spiro D., Caler E., Zhao Q., Crabtree J., Allen J.E.,
RA Delcher A.L., Guiliano D.B., Miranda-Saavedra D., Angiuoli S.V., Creasy T.,
RA Amedeo P., Haas B., El-Sayed N.M., Wortman J.R., Feldblyum T., Tallon L.,
RA Schatz M., Shumway M., Koo H., Salzberg S.L., Schobel S., Pertea M.,
RA Pop M., White O., Barton G.J., Carlow C.K., Crawford M.J., Daub J.,
RA Dimmic M.W., Estes C.F., Foster J.M., Ganatra M., Gregory W.F.,
RA Johnson N.M., Jin J., Komuniecki R., Korf I., Kumar S., Laney S., Li B.W.,
RA Li W., Lindblom T.H., Lustigman S., Ma D., Maina C.V., Martin D.M.,
RA McCarter J.P., McReynolds L., Mitreva M., Nutman T.B., Parkinson J.,
RA Peregrin-Alvarez J.M., Poole C., Ren Q., Saunders L., Sluder A.E.,
RA Smith K., Stanke M., Unnasch T.R., Ware J., Wei A.D., Weil G.,
RA Williams D.J., Zhang Y., Williams S.A., Fraser-Liggett C., Slatko B.,
RA Blaxter M.L., Scott A.L.;
RT "Draft genome of the filarial nematode parasite Brugia malayi.";
RL Science 317:1756-1760(2007).
RN [2] {ECO:0000313|EMBL:CDP94826.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FR3 {ECO:0000313|EMBL:CDP94826.1};
RA Gao Y.W., Fan S.T., Sun H.T., Wang Z., Gao X.L., Li Y.G., Wang T.C.,
RA Zhang K., Xu W.W., Yu Z.J., Xia X.Z.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|WBParaSite:Bm9636.1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (DEC-2019) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M67C family.
CC {ECO:0000256|ARBA:ARBA00010981}.
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DR EMBL; LN856931; CDP94826.1; -; Genomic_DNA.
DR RefSeq; XP_001899109.1; XM_001899074.1.
DR STRING; 6279.A0A0K0JZZ2; -.
DR EnsemblMetazoa; Bm9636.1; Bm9636.1; WBGene00229897.
DR GeneID; 6102540; -.
DR KEGG; bmy:BM_BM9636; -.
DR WBParaSite; Bm9636.1; Bm9636.1; WBGene00229897.
DR CTD; 6102540; -.
DR WormBase; Bm9636; BM19253; WBGene00229897; -.
DR OMA; FILYMRY; -.
DR OrthoDB; 5490729at2759; -.
DR Proteomes; UP000006672; Unassembled WGS sequence.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:InterPro.
DR GO; GO:0140492; F:metal-dependent deubiquitinase activity; IEA:InterPro.
DR CDD; cd08066; MPN_AMSH_like; 1.
DR Gene3D; 3.40.140.10; Cytidine Deaminase, domain 2; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR InterPro; IPR000555; JAMM/MPN+_dom.
DR InterPro; IPR037518; MPN.
DR InterPro; IPR044098; STAMBP/STALP-like_MPN.
DR InterPro; IPR015063; USP8_dimer.
DR PANTHER; PTHR12947; AMSH-LIKE PROTEASE; 1.
DR PANTHER; PTHR12947:SF13; FI19924P1; 1.
DR Pfam; PF01398; JAB; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR SMART; SM00232; JAB_MPN; 1.
DR SUPFAM; SSF102712; JAB1/MPN domain; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50249; MPN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000006672};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 176..310
FT /note="MPN"
FT /evidence="ECO:0000259|PROSITE:PS50249"
SQ SEQUENCE 345 AA; 38750 MW; 2FD633E79AD88E81 CRC64;
MERSVDVICD PRLRMRIILN MAATQEVSPS VPINRYYRSL NEMYRVAGFC IEDKDYERAF
IYYMRFVSLA VESLPNHKQY NGFSSAEKAK AEAVLGDAFV KAESLKEQLK KKYEEEAVLA
RQSAKKTTAD NVAVIGKNMS VRDVVARNRF LEIVDHKKSG SAAVMFDSRN LAHKEVVVAA
DLVENFVQLA QVNTNRNVET CAILCGSLIT GGVCRITHAV IPKQTGAADS CDTHNEEEVF
AYQDANNLIT LGWIHTHPSQ TAFLSSVDLH THCSYQLMLS EAVAIVVAPK FNEVGIFRLS
ERGMKEINEC RKVGFHPHEN SSALFFYCHD IRFENSLTAT VVDLR
//
