ID A0A0K0N6Z8_9CAUD Unreviewed; 280 AA.
AC A0A0K0N6Z8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=GMA2_72 {ECO:0000313|EMBL:AKJ72610.1};
OS Gordonia phage GMA2.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes.
OX NCBI_TaxID=1647283 {ECO:0000313|EMBL:AKJ72610.1, ECO:0000313|Proteomes:UP000221359};
RN [1] {ECO:0000313|EMBL:AKJ72610.1, ECO:0000313|Proteomes:UP000221359}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26241321;
RA Dyson Z.A., Tucci J., Seviour R.J., Petrovski S.;
RT "Lysis to Kill: Evaluation of the Lytic Abilities, and Genomics of Nine
RT Bacteriophages Infective for Gordonia spp. and Their Potential Use in
RT Activated Sludge Foam Biocontrol.";
RL PLoS ONE 10:E0134512-E0134512(2015).
CC -!- SIMILARITY: Belongs to the thymidylate synthase family.
CC {ECO:0000256|ARBA:ARBA00009972}.
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DR EMBL; KR063281; AKJ72610.1; -; Genomic_DNA.
DR Proteomes; UP000221359; Genome.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR PANTHER; PTHR11548:SF1; THYMIDYLATE SYNTHASE-RELATED; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000221359};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 98..228
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
SQ SEQUENCE 280 AA; 31751 MW; 9DEF3CD37ED7E6C8 CRC64;
MFRYDSPGEA YFAILRQIVA QGQSVPSRAG GTFEIENFSC VFEDSSHAVQ PARPNFSPLL
GLMEGAQLVG SLARPRLMDT LWPKYAAYTD HHGDYGDRVG YGDQIQYVVD TLIKTPDSRR
AILNLWQPLQ DTQPGFTDYP CTLNIGFRIR EDRLNMSVTM RSNDIWRGAS SDFIQFSMLH
QTVAALVGIE PGKYFHNAYS LHLYESDWEA ASDSIKNFEK KSHDIVITPL AKPGWTYDQT
QLECRRALAA SKYEQPQTDM GKTIASLQFA RQRKLFSVDE
//
