ID A0A0K0Y7A8_9RHOB Unreviewed; 652 AA.
AC A0A0K0Y7A8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=parE {ECO:0000313|EMBL:AKS46742.1};
GN ORFNames=OSB_22050 {ECO:0000313|EMBL:AKS46742.1}, SAMN05444287_1865
GN {ECO:0000313|EMBL:SIO20371.1};
OS Octadecabacter temperatus.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Roseobacteraceae; Octadecabacter.
OX NCBI_TaxID=1458307 {ECO:0000313|EMBL:AKS46742.1, ECO:0000313|Proteomes:UP000067444};
RN [1] {ECO:0000313|EMBL:AKS46742.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SB1 {ECO:0000313|EMBL:AKS46742.1};
RX PubMed=26358607;
RA Voget S., Billerbeck S., Simon M., Daniel R.;
RT "Closed Genome Sequence of Octadecabacter temperatus SB1, the First
RT Mesophilic Species of the Genus Octadecabacter.";
RL Genome Announc. 3:e01051-15(2015).
RN [2] {ECO:0000313|Proteomes:UP000184809}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26878 {ECO:0000313|Proteomes:UP000184809};
RA Jaros S., Januszkiewicz K., Wedrychowicz H.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:SIO20371.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 26878 {ECO:0000313|EMBL:SIO20371.1};
RA Varghese N., Submissions S.;
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
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DR EMBL; CP012160; AKS46742.1; -; Genomic_DNA.
DR EMBL; FSRP01000001; SIO20371.1; -; Genomic_DNA.
DR RefSeq; WP_049835023.1; NZ_FSRP01000001.1.
DR AlphaFoldDB; A0A0K0Y7A8; -.
DR STRING; 1458307.OSB_22050; -.
DR KEGG; otm:OSB_22050; -.
DR PATRIC; fig|1458307.3.peg.2223; -.
DR OrthoDB; 9802808at2; -.
DR Proteomes; UP000067444; Chromosome.
DR Proteomes; UP000184809; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd16928; HATPase_GyrB-like; 1.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR002288; DNA_gyrase_B_C.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR005737; TopoIV_B_Gneg.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR PANTHER; PTHR45866:SF4; DNA TOPOISOMERASE 4 SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF00986; DNA_gyraseB_C; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01098; TOPISMRASE4B.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:AKS46742.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000067444};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 433..547
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 652 AA; 71874 MW; 9FF2B60677B8223F CRC64;
MANDLLSGQT PSDYDASSIQ VLEDMEHVRL RPGMYIGGKD DRALHHMVAE IVDNSMDEAV
AGHATWIEVE LHENGHVTVR DNGRGIPTDP HPSDPTKSTL EIIFCTLNAG GKFSGDNYET
SGGLNGVGSS VVNALSDHVR VEVARNKELV AMEFSRGVPQ TKLETVGAAP NRRGTAVTFH
PDPEIFGSLR LKPARLFAMA RSKAYLFSGV EIRWKTAIAD GDTPMEAKFH FPGGLSDYLK
ERLDGATVYS EVPFAGTVDF RDKYNEVGKV EWAVNWTPSR DGFIQSYCNT VPTPEGGTHE
QGFWTAILKG IRDYGDRVSN KKAKLINRDD LTTGGCALVS IFVRDPQYVG QTKDRLSNES
ATKMVEGSVR DHFDNWLASD TKSAGAILDF LVLRAEERLR RKQEKETSRK TATAKLRLPG
KLTDCSNKNR EGTELFIVEG DSAGGSAKMA RNRKTQALLP LKGKILNVMG AASNKLGTNA
EISDLTQALG VQLGAKFNVD DLRYDKVIIM TDADVDGAHI AALLMTFFFS QMRPMIDAGH
LYLACPPLFR VTQGAKREYC LDEAEKNEVL ARGLGGSGKM DVSRFKGLGE MDHKDLKETT
MDPASRKLIR VSIDEDEPGE TGDLVERLMG KKPEMRFQYI QENARFVEEL DV
//
