ID A0A0K1EF47_CHOCO Unreviewed; 1810 AA.
AC A0A0K1EF47;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AKT39491.1};
GN ORFNames=CMC5_036380 {ECO:0000313|EMBL:AKT39491.1};
OS Chondromyces crocatus.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
OC Chondromyces.
OX NCBI_TaxID=52 {ECO:0000313|EMBL:AKT39491.1, ECO:0000313|Proteomes:UP000067626};
RN [1] {ECO:0000313|EMBL:AKT39491.1, ECO:0000313|Proteomes:UP000067626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cm c5 {ECO:0000313|EMBL:AKT39491.1,
RC ECO:0000313|Proteomes:UP000067626};
RA Zaburannyi N., Bunk B., Maier J., Overmann J., Mueller R.;
RT "Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals a
RT high potential for natural compound synthesis and the genetic basis for the
RT loss of fruiting body formation.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012159; AKT39491.1; -; Genomic_DNA.
DR RefSeq; WP_050431565.1; NZ_CP012159.1.
DR STRING; 52.CMC5_036380; -.
DR KEGG; ccro:CMC5_036380; -.
DR PATRIC; fig|52.7.peg.4011; -.
DR OrthoDB; 7617297at2; -.
DR Proteomes; UP000067626; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR049490; C883_1060-like_KR_N.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR020802; PKS_thioesterase.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR001031; Thioesterase.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF21394; Beta-ketacyl_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF00975; Thioesterase; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM00824; PKS_TE; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000067626};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..439
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1450..1525
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1353..1382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1810 AA; 196428 MW; 015F9AB55C7B298F CRC64;
MDPLEQPVPE DHIAIIGMAC NFPGARNAEA YWQNIRDGVE SIVPLSEQDL AAAGVPPEIA
SDPSYVRARA VLDGVEWFDA AFFSMTPREA EILDPQHRIF LECTWEALEH AGYNPDGFNG
SIGVYGGGSG HNTYFLSNLY PNHDLMRAME YQILLANDKD FLTTRTSYKL NLRGPSVTVQ
TGCSTSLVAV HMACQALLTY QCDMALAGGV AINVPTRSGY LYRHGMILSP DGRCRAFDAE
AQGTVVGNGA GVVVLRRLED ALDSGDHILA VIRGSAVNND GAAKIGFTAP GVEGQAQVIA
QALAMAETNP ETISYVEAHG TGTRLGDPIE IAALTRAFRA RSEGRRNGWC AIGSVKTNIG
HLDVAAGIAG LIKVIQALRN REIPPSLHYK RANPEIDFAS SPFKVSTELR AWESTGNPRR
AGVSSFGIGG TNAHVVVEEA PHAAAAPGGR PWQLLLLSAR TRTALDSVSE NLVGYLRKWP
DVSLPDVTFT LQVGRKAFPH RRMLICKDAE EAATLLSTLG DRRVLTQLEE SIDRPVVFMF
SGQGTQYVGM AQELYEREPT FRAGIDLCAA MLQPELGLDL RDVLYPQPSR EAWAAEMLKQ
TRLAQPALFV IEYALATLWM EWGLKPAAMI GHSLGEYVAA CIAGVFSLSD ALTLVAKRGH
LMQEMPVGAM LSVPLPEADL KPFLGNLSLA AVNSPSACVV AGPIEEVRAL EDRLLVECDV
ECQWLQTSHA FHSAMMEPVL EPFLAVLRRI PRLAPKIPIV SNVTGSWLSS GEAQSAEYWA
RHLREPVRFL DGLGEVLVDP ARALLEIGPG RVLSTLARQH PSRGSGRVVL SSIRQPQHPQ
SDVGFLLETL GQLWLSGIRI DWAGFHTHEP RRRVPLPTYP FERNRYWIEA PQPLSGAVRP
PARPAPAMPG LLQLPAWKRS VLSGSVKRSA QPRDGRCCLL YADSHGLGAR MEMRLRRDGY
EVILVRPGES FAAEGATAFT VDPTSASDHA SLLGALRRAG RVPSMILFLW GVTTPTRAPL
DAARAEAAQV FGFHSLMALA QALGEVGARE EVRLGVVTSY MHKVTEGAAL CPEKTTVLGP
CRALSREYGN VSCISIDVDL PEPRTLQEGR LIDQILAEVS LERTESIIAY RNGERWIRTY
EPARMDRPDG LPSRIREGGV YLIIGGLGFL GSTFAEHLAR VARARLILTG RTVLPPRAMW
EELASSEEEA SAQLRRKIRT VLQLERLGVE VVCMSADVTR IDDMREVVGR AVDHFGRIDG
VIHAAGSTRT GSIQGTSREE AEAVLAPKLV GAVVVDDALR GLRPDFILLC ASRQAVLGGA
RLASQSAAST FLGAFAQRQA AVGGPLTIAV EWDPWQRSES SDDRTPGDGV ESGHGVSSSA
GHVLSREEVL DAWMRILTNP TPQVVVAKRE EVARQRQSAS SIAPPSKEVD SESIPRSVHP
RPDLGTAYVA PRDPLERAIA ETWEKLFGIE RIGAHDNFFD LGGDSLLAVQ VISRLRGVVN
MDLPGHSLLN APTVAALAEL IAQSDSPSST SLSRRRPARL LPDSLVLIKA GTTRPLFLMH
PVGGHVYFYH DLASCLDSSQ PVYGLQAQGI DGKGPPLTRI EEMAARYLEA VRQIQPEGPY
MLGGASFGGI IAFEMAHQLL SGGQRVSLLT MMDTPAPSAV LPQQHLDSTE RLAYLISGDP
SLPIPSEEFR DLSPDEQLLH VLRRKKGVSR MFPKLALPEL ASFRKIVTAN LQAALSYAPR
PYPGRVLFFQ ASERDTLSVS APSNGWVELA RGGVAFYEVP GNHITMNLPP NVAAIAQPLQ
KSIAAIQDEE
//
