ID A0A0K1EIL6_CHOCO Unreviewed; 1910 AA.
AC A0A0K1EIL6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AKT40700.1};
GN ORFNames=CMC5_048560 {ECO:0000313|EMBL:AKT40700.1};
OS Chondromyces crocatus.
OC Bacteria; Myxococcota; Polyangia; Polyangiales; Polyangiaceae;
OC Chondromyces.
OX NCBI_TaxID=52 {ECO:0000313|EMBL:AKT40700.1, ECO:0000313|Proteomes:UP000067626};
RN [1] {ECO:0000313|EMBL:AKT40700.1, ECO:0000313|Proteomes:UP000067626}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cm c5 {ECO:0000313|EMBL:AKT40700.1,
RC ECO:0000313|Proteomes:UP000067626};
RA Zaburannyi N., Bunk B., Maier J., Overmann J., Mueller R.;
RT "Genome analysis of myxobacterium Chondromyces crocatus Cm c5 reveals a
RT high potential for natural compound synthesis and the genetic basis for the
RT loss of fruiting body formation.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP012159; AKT40700.1; -; Genomic_DNA.
DR RefSeq; WP_063796633.1; NZ_CP012159.1.
DR STRING; 52.CMC5_048560; -.
DR KEGG; ccro:CMC5_048560; -.
DR PATRIC; fig|52.7.peg.5365; -.
DR Proteomes; UP000067626; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000067626};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..453
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1779..1853
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1860..1880
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1910 AA; 202571 MW; E969CFC109CE9A5E CRC64;
MPEPVNFRQL LEQQFVKTEK LKAQLKKLEA AQSEPIAILG MGCRFPGGGT NPEAFWRALR
EGVDGIQRIP SERWRTDGGT DEPPETLWGG FLGAVDGFDP AFFGIAPREA ESLDPQQRLL
LEVTWEALEN AGQAPDRLVG SRTGVFVGIA TTDYQRQVLT RAMPELDAYA LTGNLSSVAA
GRISYVLGLQ GPCASIDTAC SSSLVAAHFA CQSLRNRECE LAIVGGANLL LSPVMMRLLA
KTQGLSPDGR CKAFDASANG FVRGEGCGVV VLKRLSDALR DGDPIVALIR GSAVNQDGRS
TGLTAPNVLS QQALLRQALE NARVSPAQIG YVEAHGTGTA LGDPIEFEAL KEVLGAPRVD
GSTCTLGSVK TNIGHLEAAA GIAGLIKTVL ALQHEVIPRH LHLRTLNPRI SLDGTPFALP
REERTWAAGS APRMAGVSSF GISGTNAHLV LEEAPRPPAN TDAHAAPSDD AAKRPLVLPL
SARSPEALTA LARAHQQHLD GLGDDPRALE DLVFTAGTRR THHEHRLAVV GQDREAIGAA
LRAFTQGQAH PGTSSARLTS EVRPRVAFVF PGYGGQRVGM GRQLLAEEPV FAEAIAACDA
ALRAHVDWSV TALLRGDPDA PALQRIDVVQ PALFAIAIGL SALWRSWGVT PDAVVGHSVG
EVAAAHVAGV LGLEDAARLV CHRSRLLHEI SGQGAMGVVE LTEEEATARL AGREHLLSIA
VINSPRSIGI AGDPAALDAL LATLEAEGIF CRRVKVDVAA HSPKVDPLVP RLVDALGSLR
PEPARCPLYS TVTGALEDGG RFDAAYWGRN LREPVQFARA VQRLHDDGIT LFVELGPHPV
LLPAIESTFR RPGQVTVAAS MRREQPERAT LLEAVGTLYT RGYPIAWAAM SPATARCAKL
PTYPFQRSRY WMAPAASHAV VGAHPLLGAR LTSSLHPGTR FWETSIGPSA LAYLADHQVQ
GAAVLPASAY LEMAVAAAWD ALGVETLALE QVSFREAMTF RIGEDIAVQT VIELHGPGVA
SFRIASRAGA EGRLHDVQWT VHATGQIRWQ PEATSTPVLA TFDPTPSAEP RRLAEALADV
RARCATELDR AAYYEALADR GITYGPAFQG VLRAWKGAGE ALCQIRLPED VAAQRAAYRI
HPALLDASFH VLMAAMVEAR DDGRPAIPVG LRRLQIHRRP DGELWSHGRI PEARVEEGHF
EADLGLLGAD GRLLVEVDGL RLQRLDPPPE AATDDTSLLT TTWEREPLAA PADGPIAARA
PRGRWLILGD DGGLAEPLAA ALTAQGESVV RAVSSASSST SLEVHRVEID APAAFDALLR
TAFADGVPCA GILHLWALEA TPAERTTLDS LDRDQRRICG SALHLVQGLT RSNLRTPPRL
WFVTRGAQAV DASGRAVSVA QAPLWGLART IWLEHKELPC SRVDLDPDAP PDEVDALVRE
LLSGVREDEL ALRATGRHVG RLGRSATLAA SPGDAVDTAG DVGVAGATLV RADATYLVTG
GLGGLGLSVA AWLVERGARH LALLGRNGAA TAAQIEAVRA LEAAGAEVRI AALDVADRAQ
LAQLLDDLQR TMPPLRGVLH AAGVIDDGLL AAQDLTRFHR VMQPKIAGSW NLHELTRSAP
LDFFVLYSSA AALLGAPGQG NYAAANAFMD ALAHHRRALG APALSIAWGI FSEAGIAARA
GTDSRLAQQG FGHLTPAEGA SLLGRLLGGG AGAPGAAGEA AHLGVARVNL RQWVAFYPQI
ASAPRLARLV GRAAVRKPPT GDEGILAAIR ARTPAKRQAL VEQLLCEHVA RVVRVDPARI
QPEAPLKGLG IDSLMGLELR NRLESILGIT LSATLVWTYP SIAALAAHLL EKLDLTAEPT
PLHATPAKDP AARDEEAATE ERMAALQDLT DDEKTALLDD KLAALEALLQ
//
