ID A0A0K2APP9_STRA7 Unreviewed; 271 AA.
AC A0A0K2APP9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA {ECO:0000313|EMBL:AKZ54896.1};
DE EC=2.1.1.226 {ECO:0000313|EMBL:AKZ54896.1};
DE EC=2.1.1.227 {ECO:0000313|EMBL:AKZ54896.1};
GN Name=tlyA {ECO:0000313|EMBL:AKZ54896.1};
GN ORFNames=SAM23877_1847 {ECO:0000313|EMBL:AKZ54896.1};
OS Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 /
OS NBRC 12836 / NRRL B-2516).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=278992 {ECO:0000313|EMBL:AKZ54896.1, ECO:0000313|Proteomes:UP000061018};
RN [1] {ECO:0000313|Proteomes:UP000061018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL
RC B-2516 {ECO:0000313|Proteomes:UP000061018};
RX PubMed=26410452; DOI=10.1016/j.jbiotec.2015.09.020;
RA Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S., Pernodet J.L.,
RA Leblond P.;
RT "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT spiramycin producer.";
RL J. Biotechnol. 214:117-118(2015).
CC -!- SIMILARITY: Belongs to the TlyA family.
CC {ECO:0000256|ARBA:ARBA00029460}.
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DR EMBL; CP012382; AKZ54896.1; -; Genomic_DNA.
DR RefSeq; WP_053128568.1; NZ_CP012382.1.
DR AlphaFoldDB; A0A0K2APP9; -.
DR STRING; 1889.SAM40697_1665; -.
DR KEGG; samb:SAM23877_1847; -.
DR Proteomes; UP000061018; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004538; Hemolysin_A/TlyA.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR047048; TlyA.
DR NCBIfam; TIGR00478; tly; 1.
DR PANTHER; PTHR32319; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR32319:SF0; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF01479; S4; 1.
DR PIRSF; PIRSF005578; TlyA; 1.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:AKZ54896.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000061018};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW Transferase {ECO:0000313|EMBL:AKZ54896.1}.
FT DOMAIN 7..74
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
SQ SEQUENCE 271 AA; 28407 MW; C1672AA908AF1ECA CRC64;
MAGVARRRLD AELVRRKLAR SREHASQLIA AGRVSVGKTV ATKPATQVET AAAIVVTADD
GDPDYVSRGG HKLAGALSAF VPQGLVVEGR RALDAGASTG GFTDVLLRAG AAHVVAVDVG
YGQLAWSLRQ DERVTVKDRT NVRELTPEAI DGELVDLVVG DLSFIPLGLV LPALVGCTRP
DADLVMMVKP QFEVGKERLG SGGVVRSAQL RAEAVRGVAR RAWELGLGVR GVTASPLPGP
SGNVEYFLWL RAGAGELDPA DVDRAVAEGP R
//
