ID A0A0K2AVN2_STRA7 Unreviewed; 253 AA.
AC A0A0K2AVN2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=HTH-type transcriptional activator TipA {ECO:0000313|EMBL:AKZ57195.1};
GN Name=tipA {ECO:0000313|EMBL:AKZ57195.1};
GN ORFNames=SAM23877_4150 {ECO:0000313|EMBL:AKZ57195.1};
OS Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 /
OS NBRC 12836 / NRRL B-2516).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=278992 {ECO:0000313|EMBL:AKZ57195.1, ECO:0000313|Proteomes:UP000061018};
RN [1] {ECO:0000313|Proteomes:UP000061018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL
RC B-2516 {ECO:0000313|Proteomes:UP000061018};
RX PubMed=26410452; DOI=10.1016/j.jbiotec.2015.09.020;
RA Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S., Pernodet J.L.,
RA Leblond P.;
RT "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT spiramycin producer.";
RL J. Biotechnol. 214:117-118(2015).
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DR EMBL; CP012382; AKZ57195.1; -; Genomic_DNA.
DR RefSeq; WP_053134833.1; NZ_CP012382.1.
DR AlphaFoldDB; A0A0K2AVN2; -.
DR STRING; 1889.SAM40697_3724; -.
DR KEGG; samb:SAM23877_4150; -.
DR Proteomes; UP000061018; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01106; HTH_TipAL-Mta; 1.
DR Gene3D; 1.10.1660.10; -; 1.
DR Gene3D; 1.10.490.50; Antibiotic binding domain of TipA-like multidrug resistance regulators; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR000551; MerR-type_HTH_dom.
DR InterPro; IPR047057; MerR_fam.
DR InterPro; IPR036244; TipA-like_antibiotic-bd.
DR InterPro; IPR012925; TipAS_dom.
DR PANTHER; PTHR30204:SF90; HTH-TYPE TRANSCRIPTIONAL ACTIVATOR TIPA; 1.
DR PANTHER; PTHR30204; REDOX-CYCLING DRUG-SENSING TRANSCRIPTIONAL ACTIVATOR SOXR; 1.
DR Pfam; PF13411; MerR_1; 1.
DR Pfam; PF07739; TipAS; 1.
DR PRINTS; PR00040; HTHMERR.
DR SMART; SM00422; HTH_MERR; 1.
DR SUPFAM; SSF89082; Antibiotic binding domain of TipA-like multidrug resistance regulators; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR PROSITE; PS00552; HTH_MERR_1; 1.
DR PROSITE; PS50937; HTH_MERR_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000061018};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 1..71
FT /note="HTH merR-type"
FT /evidence="ECO:0000259|PROSITE:PS50937"
FT REGION 140..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 77..104
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 253 AA; 28921 MW; 54512BD328A8B3A2 CRC64;
MSYSVGQVAG FAGVTVRTLH HYDDIGLLVP SERSRAGHRR YNDADLDRLQ QILFYRELGF
PLDEVAALLD DPAADPRAHL RRQHELLSAR IEKLQKMAAA VEQAMEARSM GINLTPEEKF
EVFGDFDPDE HQEEVRERWG DTDAYRQSQQ RTASYTKEDW QRIQDEADEL TRRFVALMDA
GEPADSEGAM DVAEDHRLGI ARNHYDCGYE MHTCLGEMYV SDERFTRNID AARQGLAVYM
RDAILANAVR HTS
//
