ID A0A0K2B0Q3_STRA7 Unreviewed; 325 AA.
AC A0A0K2B0Q3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Nucleotide-sugar dehydratase {ECO:0000313|EMBL:AKZ58955.1};
GN ORFNames=SAM23877_5910 {ECO:0000313|EMBL:AKZ58955.1};
OS Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 /
OS NBRC 12836 / NRRL B-2516).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=278992 {ECO:0000313|EMBL:AKZ58955.1, ECO:0000313|Proteomes:UP000061018};
RN [1] {ECO:0000313|Proteomes:UP000061018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL
RC B-2516 {ECO:0000313|Proteomes:UP000061018};
RX PubMed=26410452; DOI=10.1016/j.jbiotec.2015.09.020;
RA Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S., Pernodet J.L.,
RA Leblond P.;
RT "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT spiramycin producer.";
RL J. Biotechnol. 214:117-118(2015).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
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DR EMBL; CP012382; AKZ58955.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K2B0Q3; -.
DR STRING; 1889.SAM40697_5388; -.
DR KEGG; samb:SAM23877_5910; -.
DR UniPathway; UPA00796; UER00771.
DR Proteomes; UP000061018; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR GO; GO:0033320; P:UDP-D-xylose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05230; UGD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR044516; UXS.
DR PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000061018}.
FT DOMAIN 14..252
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 325 AA; 35289 MW; 57A09945855DA8C5 CRC64;
MSETPVSRRV WRRALVTGGA GFVGSHLCGR LLDAGADVVC LDNLATGSRR NVADLERHRG
FRFVRADATD PAALRGLPGR FDLVLHFACP ASPADYLRLP LETLDVGSTG TRNALERARA
DGARFLLAST SEVYGDPLEH PQRETYWGNV NPIGPRSVYD ESKRFAEALV TAHRQVHGTD
AAIVRLFNTY GPRMRTGDGR AVPTFIAQAL DGMPLTVAGD GGQTRSLCYV DDTVEGVLAL
AASAETGPMN IGGTDEITML ELARRVVELT GSGSRIRFVD RPVDDPGRRR PDTTLARQRL
GWQPRVGWSE GLERTIGWFA HSVAA
//
