ID A0A0K2B173_STRA7 Unreviewed; 601 AA.
AC A0A0K2B173;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:AKZ59115.1};
GN ORFNames=SAM23877_6070 {ECO:0000313|EMBL:AKZ59115.1};
OS Streptomyces ambofaciens (strain ATCC 23877 / 3486 / DSM 40053 / JCM 4204 /
OS NBRC 12836 / NRRL B-2516).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=278992 {ECO:0000313|EMBL:AKZ59115.1, ECO:0000313|Proteomes:UP000061018};
RN [1] {ECO:0000313|Proteomes:UP000061018}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 23877 / 3486 / DSM 40053 / JCM 4204 / NBRC 12836 / NRRL
RC B-2516 {ECO:0000313|Proteomes:UP000061018};
RX PubMed=26410452; DOI=10.1016/j.jbiotec.2015.09.020;
RA Thibessard A., Haas D., Gerbaud C., Aigle B., Lautru S., Pernodet J.L.,
RA Leblond P.;
RT "Complete genome sequence of Streptomyces ambofaciens ATCC 23877, the
RT spiramycin producer.";
RL J. Biotechnol. 214:117-118(2015).
CC -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC {ECO:0000256|ARBA:ARBA00005086}.
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DR EMBL; CP012382; AKZ59115.1; -; Genomic_DNA.
DR RefSeq; WP_053139386.1; NZ_CP012382.1.
DR AlphaFoldDB; A0A0K2B173; -.
DR STRING; 1889.SAM40697_5539; -.
DR KEGG; samb:SAM23877_6070; -.
DR Proteomes; UP000061018; Chromosome.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 2.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000061018}.
FT DOMAIN 15..193
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..292
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 322..499
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 502..598
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 601 AA; 63452 MW; ACC75A363A3BFDEB CRC64;
MATPLSHTSL SPFRTIAVVG LGTMGTGIAE VLARAGRDVV GIDVSEAQAT TAVAALESST
ARSVERGRLT EQERAEALAR VRTSTDLRQA ADADLVIEVV PESYEIKQQV FRELDGIVRP
ETILATGTNA LSVTRLAAES SRPERVLGLH FFNPAPAMKL VEVVSSVLTS PGAVAAVTDL
ALDLGKEPVA VGDRPGFVAD GLLFGYLNQA AAMYEANYAS REDIDAAMRL GCGLPMGPLA
LLDLIGVDTA RTVLEAMYTA SHDRLHAPAP ILRQLSEAGL TGRKAGRGFY TYEAPGSAVV
VPDALTPRAG DTPVPGRPVR SVGVAGSGTM ASGIAEVFAK AGYEVVLAAR SAEKAQTAKA
RIGKSLARGV DKGRITAEAA ARTLERITPT GTYDDFGDVD LAVEAVAEDL EVKRQLFATL
DKVCKPGAVL ATTTSSLPVV ACARATSRPQ DVIGMHFFNP APAMKLVEVV RTVLTADDVH
ATVREVCAKI RKHAVDCGDR AGFIVNALLF PYLNNAVKMV QEHYATLDDI DAAMKLGGGY
PMGPFELLDV VGLDVSLAIE KVLHREFRDP GLAPAPLLEH LVAAGCLGRK TGRGFREYAR
R
//
