ID A0A0K2G9Y2_NITMO Unreviewed; 355 AA.
AC A0A0K2G9Y2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=O-methyltransferase, family 2:Generic methyltransferase {ECO:0000313|EMBL:ALA57750.1};
GN ORFNames=NITMOv2_1322 {ECO:0000313|EMBL:ALA57750.1};
OS Nitrospira moscoviensis.
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Nitrospira.
OX NCBI_TaxID=42253 {ECO:0000313|EMBL:ALA57750.1, ECO:0000313|Proteomes:UP000069205};
RN [1] {ECO:0000313|EMBL:ALA57750.1, ECO:0000313|Proteomes:UP000069205}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NSP M-1 {ECO:0000313|EMBL:ALA57750.1,
RC ECO:0000313|Proteomes:UP000069205};
RX PubMed=26305944; DOI=10.1073/pnas.1506533112;
RA Koch H., Lucker S., Albertsen M., Kitzinger K., Herbold C., Spieck E.,
RA Nielsen P.H., Wagner M., Daims H.;
RT "Expanded metabolic versatility of ubiquitous nitrite-oxidizing bacteria
RT from the genus Nitrospira.";
RL Proc. Natl. Acad. Sci. U.S.A. 112:11371-11376(2015).
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DR EMBL; CP011801; ALA57750.1; -; Genomic_DNA.
DR RefSeq; WP_053379029.1; NZ_CP011801.1.
DR AlphaFoldDB; A0A0K2G9Y2; -.
DR STRING; 42253.NITMOv2_1322; -.
DR KEGG; nmv:NITMOv2_1322; -.
DR OrthoDB; 9767938at2; -.
DR Proteomes; UP000069205; Chromosome.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ALA57750.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000069205};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:ALA57750.1}.
FT DOMAIN 13..89
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 122..311
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT REGION 328..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 237
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 355 AA; 39385 MW; F5E2988E0E7678A5 CRC64;
MSSAITTFEE FRDAVAGYRL PRVLLAALEL DLFTTVGDRT WTIPALAHEM KVSERGLAIL
CRNVAMAGLL RKKGDRYSNS RLGATMLNAR HPAYRGGYLD LIKSHWTDWI RLPESVKSGL
PIDHDTADDP DWRRRFTWAM HHRTLDKAPA IAAQVDLHGA ASLLDLGGGP GTYARAFLAK
NPKLHATVCD REAALEVARE IAAGDPAGRR LSYLPLDFAK DPVPGTYDVI WYSNVLHIYS
PADNQAIFRR ALAALNPGGR LIIQDALLHD REGLFPADAS LFAVSMLLFT EGGDTYSARE
TARWLKAAGF RLVRSLTIKG KTADWEDGLL EARAPGPRPE KPARRSRPRE SSRRR
//
