UniProt: A0A0K2GG96

Database: UniProt
Entry: A0A0K2GG96_NITMO

LinkDB:  A0A0K2GG96_NITMO 
Original site:  A0A0K2GG96_NITMO

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Ontology (8)   
   GO (8)   
Gene (1)   
   KEGG GENES (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (8)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (1)   
Literature (1)   
   PubMed (1)   
All databases (20)   

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ID   A0A0K2GG96_NITMO        Unreviewed;       963 AA.
AC   A0A0K2GG96;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN   Name=uvrA {ECO:0000313|EMBL:ALA59975.1};
GN   ORFNames=NITMOv2_3583 {ECO:0000313|EMBL:ALA59975.1};
OS   Nitrospira moscoviensis.
OC   Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC   Nitrospira.
OX   NCBI_TaxID=42253 {ECO:0000313|EMBL:ALA59975.1, ECO:0000313|Proteomes:UP000069205};
RN   [1] {ECO:0000313|EMBL:ALA59975.1, ECO:0000313|Proteomes:UP000069205}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NSP M-1 {ECO:0000313|EMBL:ALA59975.1,
RC   ECO:0000313|Proteomes:UP000069205};
RX   PubMed=26305944; DOI=10.1073/pnas.1506533112;
RA   Koch H., Lucker S., Albertsen M., Kitzinger K., Herbold C., Spieck E.,
RA   Nielsen P.H., Wagner M., Daims H.;
RT   "Expanded metabolic versatility of ubiquitous nitrite-oxidizing bacteria
RT   from the genus Nitrospira.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:11371-11376(2015).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000256|ARBA:ARBA00038000}.
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DR   EMBL; CP011801; ALA59975.1; -; Genomic_DNA.
DR   RefSeq; WP_053380901.1; NZ_CP011801.1.
DR   AlphaFoldDB; A0A0K2GG96; -.
DR   STRING; 42253.NITMOv2_3583; -.
DR   KEGG; nmv:NITMOv2_3583; -.
DR   PATRIC; fig|42253.5.peg.3534; -.
DR   OrthoDB; 9809851at2; -.
DR   Proteomes; UP000069205; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   CDD; cd03271; ABC_UvrA_II; 1.
DR   Gene3D; 3.30.190.20; -; 1.
DR   Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 2.
DR   Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 4.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   InterPro; IPR041102; UvrA_inter.
DR   NCBIfam; TIGR00630; uvra; 1.
DR   PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR   PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   Pfam; PF17760; UvrA_inter; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000069205};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          143..255
FT                   /note="UvrA interaction"
FT                   /evidence="ECO:0000259|Pfam:PF17760"
FT   DOMAIN          306..369
FT                   /note="UvrA DNA-binding"
FT                   /evidence="ECO:0000259|Pfam:PF17755"
FT   REGION          846..870
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   963 AA;  105802 MW;  9FB7E24ADA676DF8 CRC64;
     MALTPPSPDS SHHLVVEGAR QHNLKNISLR IPHDRVTAIT GLSGSGKSSL AFDTIFAEGQ
     WRYVESLSTY ARMFLDKVAR PDVERILNVR PAIAIEQKNQ VRTARSTVGT TTEIADLLRL
     LFAKIGKPVC PDCRQEARSY HPEAVTDDLL KRLLGARAMI LFPVAAPNAT QTPAFTQTLL
     TRGFTRLKVG DQIIDLHDLS PRCPLPIVGE GKGEGARLLY VVLDRLIIRA DDRARLVEAV
     ETAFREGEGT CVVDVIGHGP QSYSTRYLCQ GCGRRFEPLR PVLFSFNHPL GACPECKGFG
     NVLRYDPDLV IPDEGKSLSQ GAIEPWSKPG TDWWQKQMLL AMKRRGVDLT VPFKDLPKAT
     QQLLWQGDRS FDGINDFFMY MEGKRYKLHV RVLLSRYRTP FDCPGCHGSR LKPEALFVRI
     AGTDIHRAMG LTVEGLREWV EFLPLRPFEQ EIAADILRQL TAKLGFLLRV GLGYLTLDRQ
     TKTLSGGEAQ RVALANQLGS RLVGTLYVLD EPTIGLHARD TDLLAGILKD LAAVGNTVVV
     VEHDRRMIES ADYVVEMGPR SGEHGGQVVC AAPTPAFIAD SRAITARYLR GEDTIPLPKI
     RRSGSGKFLV IAGAAEHNLK DLLIRIPLGM LICVTGVSGS GKSTLVEDTL YRAVARAFRV
     ESLPMGRFKA IKGLEHLKGI RLIDQQPIGR TPRSNPITYL KAFDEIRQLF AAELDALKRG
     FTPGHFSFNA TGGRCERCEG SGVEKLEMYF FEDIYAPCEV CEGKRFKPEV LQIRYRGKNI
     SDVLNMTVDG ALAFFAGAPK LQERLHLLSS IGLGYLRLGQ SATTLSGGEA QRLKIAAELI
     SGGGLSHQGT VPLPGRTNGD RHRPSRSQSP RDVLYIMDEP TTGLHFEDIK KLLAVLNKLV
     NAGNTLVIVE HNLDVIKCAD WIIDLGPEGG AAGGQIVAEG RPEQVAKVAA SHTGRFLAKA
     LAG
//

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