ID A0A0K2GXZ3_9CORY Unreviewed; 3836 AA.
AC A0A0K2GXZ3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Peptide synthetase {ECO:0000313|EMBL:ALA66664.1};
GN ORFNames=CLAC_01730 {ECO:0000313|EMBL:ALA66664.1};
OS Corynebacterium lactis RW2-5.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales;
OC Corynebacteriaceae; Corynebacterium.
OX NCBI_TaxID=1408189 {ECO:0000313|EMBL:ALA66664.1, ECO:0000313|Proteomes:UP000058446};
RN [1] {ECO:0000313|EMBL:ALA66664.1, ECO:0000313|Proteomes:UP000058446}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RW2-5 {ECO:0000313|EMBL:ALA66664.1,
RC ECO:0000313|Proteomes:UP000058446};
RA Ruckert C., Albersmeier A., Lipski A., Kalinowski J.;
RT "Complete genome sequence of Corynebacterium lactis DSM 45799(T), isolated
RT from raw cow milk.";
RL Submitted (OCT-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; CP006841; ALA66664.1; -; Genomic_DNA.
DR STRING; 1408189.CLAC_01730; -.
DR KEGG; clw:CLAC_01730; -.
DR PATRIC; fig|1408189.4.peg.345; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000058446; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 4.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 4.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 8.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 693..767
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2257..2330
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3757..3834
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 958..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..975
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3836 AA; 418232 MW; 350630F57053AB3E CRC64;
MLRRYLQESP AATNDNLALA LALGIFYWVS RRVDPVGHDG IDVAFIDCIA PKQESVQHVL
RGDQRFLELL TLREQESFGS RDLGQHGQLC VEGVEGNRTS VRIRVEGEMC GSRSSLEPQD
SGTRDISVDI EINLPSHADE SSLRALNESA VKNTVRDVLA FPDRSLATVG GPSENERIEQ
QYRWNQTDRD RDRPDLISLL LDRAERTPEA PAVVHGDLKL TYSELVAHAT SVAKELRAKG
IGDGESVGIS LPRSAEMIVG IVAVLLAGGS FVPLDPSWPE SRRESVSRDA GLAYVLTEAN
CVVGDSSEVG VESARKLFTP PSEDDVAYVI FTSGSTGRPK GAMIRHGAIV ERLLWQRDQI
LVFGQDDASL FKAPLAFDIS INEIFLPLVS GGRVVVAEPG VEQDPTRLAR LIHKEQVTFA
YLVSSVLDVM LWQSEHTNLL ESLRHLWCGG EMLTQALFQR FRRQLAIPLY HGYGPAEATI
GVSHVIYRGD EDRLNTSIGV ANPNCRLYVL DENLRVVPHQ EIGELYVAGY LLSEGYINAP
GLTASRFVAD VFASDGSRMY RTGDLVRRLD DGSLEFVGRS DNQVKIRGMR LELEDVESAL
VGHPAVESAS VIAREGRLLG YVTVDKASTD ASALGTDAVP IRNWCADFLP EYMVPAIVTV
LDELPRTVNG KVDRRALPEP TWTLTNDSPA DAERDGETVA LIAEAMAETL KIPSSGAHTD
FFDIGGDSLR AITLLSTLGR RGIEVSVGDI FTARTPHQLA RLAEDRGKRA EDPDDNPVGE
VDSLPILRWF DSVAQHFDGF IQSVEFAVPD CVDEQLARQM ISKVLDAHPA LTARVHRNPL
RLELPDTKGE SAVVLARSTD TDALVSLLDP DHGVVLVAGL IPGRLRLVAH HLVVDGVSWD
IIGEDLAAAY RGEELLAERT SLRRWSQLLQ SAVDRGSFAE QASASLATLP EVDEPLHEPQ
LSSLTDSAST TATVRDERSV VHETSVQTTE EVLQKVPQAF RTGANAVLLT ALSVTLARWR
RSSQTWSLVE LEGHGRETRY VPGPHGREAD LSRTVGWFTC LYPVLIDPTD AALDSAGMKE
PHDTSAPPLA LALNAVKDQL NAIPGNGVPY QAQTWLGHAA ETHSQAQVLF NYLGRVSTGA
GDFLPAETTG QLGERRDPRQ PLVRELEFNA IAEETDEGYV LRTTISWANG RISQDRIDEL
LETWDAALQE VAALSEVRML SQGDVEPAPV TAEDLAHITA RSTKHLVDVL PLTALQHGMY
FQALFDESAS SYVEQQVLHV ECRETFDRER FTRAVRRLVQ RHPLLSARPW ETSAGDMVAV
IDPGIAENMH VDYVDVAVPD TLGENELSEW LMQRAETIAA EDLTQGIALQ PVSADGLLEP
LMRWTVLLPS GNAVDQAMVS PKTTGQESGV PPIAVIQTVH HLVADGWSVP IMLRDILEIY
RDDDARIPRY NPQAGIAGSV RWVARRDHEE DLGIWRSEMF NARPTVLCSG ASQSLERREL
DIRDTRVAQL SQRAREAGVG VPDVVHAAWG LVLRALIGCE PGADVVFATS VSGRDIPVPG
VTDAVGMQLN TIPVVAPGEA DPTLPITSLL RAMMQHNNRV RDVQHVSLSD IARDMGTNAS
ELLDTLMVVE VPLSAEDLDC PGSPLTVADV RNNGVPHFPL SVVVNPSADN PLRLIYDPQR
ISDLRVERIA QMLAESVDSL LSRAGSVTTV GEISTMLGSI ASSAADSFTL DSLWRRNTEH
FNDRIALSCV DDSGAAQQWT YKQLDDKAQC LLAELERRVR VDKPRVVLLL DRDVWQVAAI
VATALSGGTF IPVDSLSPQD RIELIVDSCQ PDAVIVTPSA RETLDQMVDC PVIVASEEAM
HQESQPRVPL TGAVASRNTK ERVAVRAAED DIAYVIYTSG STGRPKGVAV THANVVSMLQ
NARSHVEFSK QDVWSISHSF AFDFSVWELW GAFSSGGHAV VMPYALMRSP EDAGRVLQEQ
GVTILSQTPT SFSSLEPYLG AQSAVRVVVF GGESLEAKTA ASYCAAHPRI RFINMYGITE
TTVHVTAHEC SVDTGEPKCP IGHPMDGLRV YVLDNNLQPV RAGETGIIYV SGSQVTAGYM
GLPGMTASRF VADPFTGDGS RMYCSNDLAT VLSNGHLDYV GRADRQVQLR GYRVERGEIE
AALEAVPGVR EAAVVIVETP EGQVAGALLI VDPREDANAV IARAAAKARK ALPAYMVPQR
FAVRAEMPQT INGKRDDRAV VELLGEDVEQ PKQTDSSDTV EMIARAIAEA LRLDPEQVDA
DSDFFRLGGD SILAIRVTHV LARAELSVTP RDFFLGRTPR LIAERVEAKL GERVRSVNKQ
NHTNTDEQMN IAYQKSTDPA EQAGAFPASA MLRRQLGLGM SDRFVQAHRL DLGPVGVEQL
RQAVQLVAEA HPILRAQVET HRAAEQAEAQ RASARFVIPE PADSSVHKQG EEVGPLVLPT
LSIDTLIEHI DLERGRTLVL GCVDGYVKAV AHHAVIDSAS WIIVEDDLRD AVAGRKVLRE
KFSYRALTQR ELIDAHAVSS PDLDHWTAVA SVPRPVEGVN QWSADLVETT TVTIGGNTAR
IMQDIAPAVM GVEVQDLVTA VVTVAVARIM GINLPSDDDV PLWAVDVEGH GRPEDRDCAR
TIGWFTTISP VTLPLTDVAH AARVAAEMRR NHEQGKAPDR RTYQGIRYTH PQGAELHSRG
AQILVNYLGR GETDTVLSVP RDPACTWTNY LVETDVWASD QQLHMDLAVI GSLISAACLE
AAINDVAQEL CELVSHAEIT TGRKAPLSVL QRGIWFQSSV SSPGAYVAQT MLTFNRKLDA
DAVVEAFQDT VTVHPAMGAS FRTNYSGLPE QTLPWSGRGI NLPVEVIEGD VETIMYADRR
AGVDLTRAPL AKAKIIPATG EQQGDTLLLT YHLILVDGWS RTTMLRTFLE RLTARSGPEG
SRENNEVVAA QPNIVDVLQD TVDETKEQTD SHYWAQRLRT LSQPTIIAPR AAALPLEPSV
CELPRQLFAE LDEDMTDALS STIRTCGVTL TSVVNAAVAV ALGQATGDPD VVFGQSVSGR
DALKDSAASD VVGVLLNTVP IRVTTRPEHT LEQLVNDVHI QRIEDMEHDA ADLGAIQKQL
GVEALFDSMV VVQNFLDLDA AAELRSRHGV VRERAEDSTH FPLTWVFTPG THLGIKLEFR
QDLVDEDLAA SVLETVTSIL RAYVDRADIP LAQLTSPSSQ VHSGSIGASD AQSQIVSWQQ
GEGIERTIVH ELADTARRFP ENVAIVDSSQ QWTFRDVVGR CSDLVRNLRI HEVSRGDTVA
IAVERSAHSV IALLGALWAG VRYVPLDLTH PDGRLQAILE DSRPALVLVD PGSKMRMERL
GDELCIDVTT MNSAAAFTSP VATPDDDAYL MYTSGSTGKP KGVVIQHRGL QNMLDNHRRK
IFAPAARDGQ VLRIAHAISF AFDMSWEELF WLTEGHEVRI FSEDLRRDAT SMVEAIHEHQ
VDVINVTPTV AEQLIAEGMF QAGQHRPRVV LLGGEAVSQN LWNALRNAEG VRGYNLYGPT
EYTINALGAG TDESALPVIG KPVDRTAAFV LDTWLRPVSH GMAGELYLAG SGLASEYFGL
PARTASSMVA CPWGAPGERM YRTGDIVRLR ADGLYEYLGR SDDQVKIRGH RVDPGDVSAA
VMRSADSRIL QCVTGSVDVS GSTALACHVV APSVCGSNPT TKKGFLTAIR MALREELPSY
MIPERWSIVE EIPMTSNGKA DFAALGSGDR IAEQGREPVG EVEAVVAELF AESLDIEPEE
VPADVDYFDL GGHSMAVIKL CALLRGEWGV SVGVREFYAL RTVERVAKRV EGGVQS
//
