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Database: UniProt
Entry: A0A0K2LAF9_9LACO
LinkDB: A0A0K2LAF9_9LACO
Original site: A0A0K2LAF9_9LACO 
ID   A0A0K2LAF9_9LACO        Unreviewed;       391 AA.
AC   A0A0K2LAF9;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   16-JAN-2019, entry version 20.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU000579};
DE            Short=HDH {ECO:0000256|PIRNR:PIRNR036497};
DE            EC=1.1.1.3 {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU000579};
GN   ORFNames=JP39_02180 {ECO:0000313|EMBL:ALB28284.1};
OS   Lactobacillus heilongjiangensis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1074467 {ECO:0000313|EMBL:ALB28284.1, ECO:0000313|Proteomes:UP000061546};
RN   [1] {ECO:0000313|EMBL:ALB28284.1, ECO:0000313|Proteomes:UP000061546}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 28069 {ECO:0000313|EMBL:ALB28284.1,
RC   ECO:0000313|Proteomes:UP000061546};
RA   Jiang X., Zheng B., Cheng H.;
RT   "Genomic sequence of Lactobacillus heilongjiangensis DSM 28069,
RT   isolated from Chinese traditional pickle.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|PIRNR:PIRNR036497,
CC         ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|RuleBase:RU004171}.
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DR   EMBL; CP012559; ALB28284.1; -; Genomic_DNA.
DR   RefSeq; WP_041498868.1; NZ_CP012559.1.
DR   EnsemblBacteria; ALB28284; ALB28284; JP39_02180.
DR   KEGG; lhi:JP39_02180; -.
DR   KO; K00003; -.
DR   OrthoDB; 1464088at2; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000061546; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000061546};
KW   Isoleucine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRNR:PIRNR036497, ECO:0000256|PIRSR:PIRSR036497-2,
KW   ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579};
KW   Threonine biosynthesis {ECO:0000256|PIRNR:PIRNR036497,
KW   ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN        7    116       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      124    303       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       7     12       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    192    192       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING      92     92       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     177    177       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   391 AA;  43081 MW;  4DBE9F866024CD17 CRC64;
     MKIAILGFGT VGKGVYKIIK KANVQTQDLS VSHILIRKNK ARLMPEMTDD MNEILNDSQT
     DVIVEAIGGI EPAHEYILAA LNHGKHVITA NKAVIAKYLK EFTEAADKHN VKFYFEASVG
     GGIPWIQGLE KALRIDNVNS ISGIFNGTSN FILDQMSRNG ESFIDVLKKA QQLGYAEADP
     SADIDGIDVA NKLCISADIA YDIDIHDHKD LPIFGIRNIT CADVKYFQAK GLAVKLIGRT
     HQKGNKFDYV VEPALFLDRT LEANTPDNYN LISLNGDTIG KLDFFGQGAG MFPTANAVVQ
     DVLDIKESKS HLKRDFNKKM EYCPELTKGD YLVRSNADVS ELFGDFQPTM EGAYLAVHQI
     PVGEMHRLMR KVLQKDAAAF MVSLPSQGAV A
//
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