ID A0A0K2LBX4_9LACO Unreviewed; 528 AA.
AC A0A0K2LBX4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN ORFNames=JP39_04980 {ECO:0000313|EMBL:ALB28765.1};
OS Companilactobacillus heilongjiangensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Companilactobacillus.
OX NCBI_TaxID=1074467 {ECO:0000313|EMBL:ALB28765.1, ECO:0000313|Proteomes:UP000061546};
RN [1] {ECO:0000313|EMBL:ALB28765.1, ECO:0000313|Proteomes:UP000061546}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 28069 {ECO:0000313|EMBL:ALB28765.1,
RC ECO:0000313|Proteomes:UP000061546};
RA Jiang X., Zheng B., Cheng H.;
RT "Genomic sequence of Lactobacillus heilongjiangensis DSM 28069, isolated
RT from Chinese traditional pickle.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the lactate permease family.
CC {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
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DR EMBL; CP012559; ALB28765.1; -; Genomic_DNA.
DR RefSeq; WP_041499411.1; NZ_CP012559.1.
DR AlphaFoldDB; A0A0K2LBX4; -.
DR STRING; 1074467.JP39_04980; -.
DR KEGG; lhi:JP39_04980; -.
DR OrthoDB; 9761056at2; -.
DR Proteomes; UP000061546; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003804; Lactate_perm.
DR PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR Pfam; PF02652; Lactate_perm; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU365092};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365092};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365092};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT TRANSMEM 26..42
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 63..81
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 186..204
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 216..240
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 246..267
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 288..307
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 341..359
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 380..396
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 466..487
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
FT TRANSMEM 507..527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365092"
SQ SEQUENCE 528 AA; 56961 MW; 3287339CE6B69CF9 CRC64;
MILIALSAVI LPLVLLGILN LPATKGMSIS AFIVLLEGYF FWKMPPKVLL ASIFQSVHKA
LPILWILFGA LMMLNILQHT GAIERINAGF HTISADMRLQ VLLVAFLFGG LIEGVSGFGT
PAMVTAPLMI ALGFSPMAAV TLALVADSTP ASFGAVGTPL TVGLSNVSER ADFLNAIGQK
ITQLDLFAGT FMPLILIFML VFLFGKNDSN HKKDFLALVP WSLFIGLVYS IFAILVSFIL
SYEFVAILAP FATIIIAIIS IKFRFILPKS VFEKPWTTST QTITAENKMS LLTAWSPYIV
VILMLLATRT INPLKQFLVN NVNLSWQNIL GFTQISSDWE FLYSPGTLLT IAVLIGLLIQ
VKSLKSFLPT AKKVVFSMKS TALALIVTLI MVQIFTNSEL NGANLPSMPM YIAKIISKYL
SSVWIIIAPF LGQLGSFVTG STTVSTLTFG QIQADIAMKA GVGKELVLAA QLIGAAAGNM
ICVHNIVSVS SVVGLSGQEG NILRKTVVPA LLYGLLVGIV GFIFTLFI
//
