ID A0A0K2QQK4_9CAUD Unreviewed; 178 AA.
AC A0A0K2QQK4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
OS Ralstonia phage RSF1.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Chiangmaivirus; Chiangmaivirus RSF1.
OX NCBI_TaxID=1689679 {ECO:0000313|EMBL:BAS04869.1, ECO:0000313|Proteomes:UP000202583};
RN [1] {ECO:0000313|EMBL:BAS04869.1, ECO:0000313|Proteomes:UP000202583}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RSF1 {ECO:0000313|EMBL:BAS04869.1,
RC ECO:0000313|Proteomes:UP000202583};
RA Kawasaki T., Fujie M., Chatchawankanphanich O., Ogata H., Yamada T.;
RT "Two Asian jumbo phage RSL2 and RSF1 infecting the phytopathogen Ralstonia
RT solanacearum share common features related to the phi-KZ-like phages.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|RuleBase:RU004474}.
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DR EMBL; AP014927; BAS04869.1; -; Genomic_DNA.
DR RefSeq; YP_009207881.1; NC_028899.1.
DR GeneID; 26634538; -.
DR KEGG; vg:26634538; -.
DR OrthoDB; 9577at10239; -.
DR Proteomes; UP000202583; Genome.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:InterPro.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PIRSF; PIRSF000194; DHFR; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000202583}.
FT DOMAIN 2..178
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 178 AA; 19996 MW; A991B05A53EFFC27 CRC64;
MKIILIAAEA ANKVIGNDGK MPWHIPEDLQ GFKNTTMGSA IIMGRKTWDS FGGRPLPGRK
NIIVSRQLDA GWTAPEGAFR VHSFKSAIKS LIAAGYDHCF VIGGEQLYRA AMPWASMIML
TKLYKSYEGD ARFPDISPLE WRMTASAQFF EASQPYSVQT YYPISERDVV KWVDLIKD
//
