ID A0A0K2RKW4_9MICC Unreviewed; 396 AA.
AC A0A0K2RKW4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000313|EMBL:BAS15468.1};
GN ORFNames=AHiyo8_37710 {ECO:0000313|EMBL:BAS15468.1};
OS Arthrobacter sp. Hiyo8.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1588023 {ECO:0000313|EMBL:BAS15468.1, ECO:0000313|Proteomes:UP000060353};
RN [1] {ECO:0000313|Proteomes:UP000060353}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hiyo8 {ECO:0000313|Proteomes:UP000060353};
RA Hiraoka S., Machiyama A., Iwasaki W.;
RT "Microbial genome analysis of tsunami-affected soil.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317}.
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DR EMBL; AP014719; BAS15468.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K2RKW4; -.
DR STRING; 1588023.AHiyo8_37710; -.
DR KEGG; arh:AHiyo8_37710; -.
DR PATRIC; fig|1588023.3.peg.3943; -.
DR Proteomes; UP000060353; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:BAS15468.1};
KW Transferase {ECO:0000313|EMBL:BAS15468.1}.
FT DOMAIN 114..151
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 78..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 396 AA; 41164 MW; 598B9CBA9560E8DB CRC64;
MYGKLPDDAG TSDGGPAGGP LVGSGPKADA VKRRPRKRPE GAASVPAAAP SAAPAAVETA
VERVAEPSAP ALSPVAAQQP AAASQTSASQ TSANQAPGLT GIGATVSGLV NRVLAKPPVR
KIARELGIDL ADVVPTGARG EVTREDLVSY QSQRDAEVDQ ADKFWGASKK PQDQRVERIP
VKGVRKATAK AMVESAFTAP HVSIFVDVDA SRTMEFVKRL KASRDFEGIK VSPLLILSKA
VIWAAARNPS VNATWVENAD GNGNAEIHVK HYMNLGIAAA TPRGLMVPNI KDAQDLSLKE
LALALNELAS TARAGKTQPS QMQGGSLTIT NIGALGIDTG TPIINPGEVA IVAFGTIKQK
PWVLDGEVIP AGSQRLAVRS TTAWWTATSL PVSWPT
//
