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Database: UniProt
Entry: A0A0K2X375_9HELI
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ID   A0A0K2X375_9HELI        Unreviewed;       400 AA.
AC   A0A0K2X375;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   08-MAY-2019, entry version 19.
DE   RecName: Full=Aspartokinase {ECO:0000256|RuleBase:RU003448};
DE            EC=2.7.2.4 {ECO:0000256|RuleBase:RU003448};
GN   ORFNames=HAL011_11690 {ECO:0000313|EMBL:CRF41375.1}, HAL013_01570
GN   {ECO:0000313|EMBL:CRF42008.1}, HAL07_14580
GN   {ECO:0000313|EMBL:CRF52993.1}, HAL09_01720
GN   {ECO:0000313|EMBL:CRF43626.1};
OS   Helicobacter ailurogastricus.
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=1578720 {ECO:0000313|EMBL:CRF41375.1, ECO:0000313|Proteomes:UP000038622};
RN   [1] {ECO:0000313|EMBL:CRF41375.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ASB11 {ECO:0000313|EMBL:CRF41375.1}, ASB13
RC   {ECO:0000313|EMBL:CRF42008.1}, ASB7 {ECO:0000313|EMBL:CRF52993.1}, and
RC   ASB9 {ECO:0000313|EMBL:CRF43626.1};
RA   Misic A.M., Cain C., Morris D.O., Rankin S., Beiting D.;
RT   "Whole genome sequences of four Staphylococcus schleiferi canine
RT   isolates.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000038622, ECO:0000313|Proteomes:UP000041394, ECO:0000313|Proteomes:UP000043437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jaenicke S.;
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-aspartate = 4-phospho-L-aspartate + ADP;
CC         Xref=Rhea:RHEA:23776, ChEBI:CHEBI:29991, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57535, ChEBI:CHEBI:456216; EC=2.7.2.4;
CC         Evidence={ECO:0000256|RuleBase:RU003448};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-lysine biosynthesis via DAP
CC       pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 1/3.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 1/5.
CC       {ECO:0000256|RuleBase:RU004249}.
CC   -!- SIMILARITY: Belongs to the aspartokinase family.
CC       {ECO:0000256|RuleBase:RU003448}.
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DR   EMBL; CDML01000038; CRF41375.1; -; Genomic_DNA.
DR   EMBL; CDMH01000006; CRF42008.1; -; Genomic_DNA.
DR   EMBL; CDMN01000005; CRF43626.1; -; Genomic_DNA.
DR   EMBL; CDMG01000009; CRF52993.1; -; Genomic_DNA.
DR   RefSeq; WP_053940689.1; NZ_FZMH01000009.1.
DR   EnsemblBacteria; CRF41375; CRF41375; HAL011_11690.
DR   EnsemblBacteria; CRF42008; CRF42008; HAL013_01570.
DR   EnsemblBacteria; CRF43626; CRF43626; HAL09_01720.
DR   EnsemblBacteria; CRF52993; CRF52993; HAL07_14580.
DR   OrthoDB; 1067792at2; -.
DR   BioCyc; GCF_001282945:G1EMS-1421-MONOMER; -.
DR   UniPathway; UPA00034; UER00015.
DR   UniPathway; UPA00050; UER00461.
DR   UniPathway; UPA00051; UER00462.
DR   Proteomes; UP000038622; Unassembled WGS sequence.
DR   Proteomes; UP000041394; Unassembled WGS sequence.
DR   Proteomes; UP000043437; Unassembled WGS sequence.
DR   Proteomes; UP000045175; Unassembled WGS sequence.
DR   GO; GO:0004072; F:aspartate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:UniProtKB-UniPathway.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd04261; AAK_AKii-LysC-BS; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR041740; AKii-LysC-BS.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR005260; Asp_kin_monofn.
DR   InterPro; IPR001341; Asp_kinase.
DR   InterPro; IPR018042; Aspartate_kinase_CS.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   Pfam; PF00696; AA_kinase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF13840; ACT_7; 1.
DR   PIRSF; PIRSF000726; Asp_kin; 2.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00656; asp_kin_monofn; 1.
DR   TIGRFAMs; TIGR00657; asp_kinases; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS00324; ASPARTOKINASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU004249};
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000726-1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000038622,
KW   ECO:0000313|Proteomes:UP000041394, ECO:0000313|Proteomes:UP000043437,
KW   ECO:0000313|Proteomes:UP000045175};
KW   Kinase {ECO:0000256|RuleBase:RU003448, ECO:0000313|EMBL:CRF41375.1};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000726-1};
KW   Transferase {ECO:0000256|RuleBase:RU003448,
KW   ECO:0000313|EMBL:CRF41375.1}.
FT   DOMAIN      263    343       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       6      9       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   NP_BIND     172    173       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   NP_BIND     208    209       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
FT   BINDING      46     46       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000726-1}.
FT   BINDING      73     73       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000726-1}.
FT   BINDING     178    178       ATP; via amide nitrogen and carbonyl
FT                                oxygen. {ECO:0000256|PIRSR:PIRSR000726-
FT                                1}.
FT   BINDING     183    183       ATP. {ECO:0000256|PIRSR:PIRSR000726-1}.
SQ   SEQUENCE   400 AA;  42636 MW;  6477512B69672539 CRC64;
     MLVVQKFGGT SMGGCARIEA VARRVIESKK LYEDLVVVVS AMGDTTDDFL NLAHYFGARS
     NQRELDRLLS SGEQISSALL AIALESMGQK ACSLSGSEAG ILTDARYTKA QILDIDTAKI
     KELLAQNFVV VVAGFQGISP SGEITTLGRG GSDLSAVALA GALHAGLCEI YTDVDGIYTT
     DPRIVPRARK IDEISYEEML ELASMGAKVL FNRSVELAKK YNIPLVTRNS FNSTEGTRIT
     SEEKILEKPI VSGIALDTDQ ARVNIVDALD YPGIAGEVFG LLAGAGINID LIVQTVARNG
     KTDINFTVPK GDLEACLHVL KNLQNIGSIE HDDKIAKVSV VGVGMRSHSG IASAVFNALA
     KENINILMIG TSEIKISVVV EVGVAELALK TLHTAFKLDL
//
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