ID A0A0K2YI39_9NOCA Unreviewed; 537 AA.
AC A0A0K2YI39;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=RHCRD62_30361 {ECO:0000313|EMBL:CRK51697.1};
OS Rhodococcus sp. RD6.2.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=260936 {ECO:0000313|EMBL:CRK51697.1, ECO:0000313|Proteomes:UP000044872};
RN [1] {ECO:0000313|EMBL:CRK51697.1, ECO:0000313|Proteomes:UP000044872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RD6.2 {ECO:0000313|EMBL:CRK51697.1,
RC ECO:0000313|Proteomes:UP000044872};
RA Wang D.B., Wang M.;
RL Submitted (MAY-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CVQP01000006; CRK51697.1; -; Genomic_DNA.
DR RefSeq; WP_050064882.1; NZ_CVQP01000006.1.
DR AlphaFoldDB; A0A0K2YI39; -.
DR STRING; 260936.RHCRD62_30361; -.
DR REBASE; 125098; M.Rsp46800ORF30361P.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000044872; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR Gene3D; 1.20.1260.30; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR038333; T1MK-like_N_sf.
DR PANTHER; PTHR42998:SF1; TYPE I RESTRICTION ENZYME HINDI METHYLASE SUBUNIT; 1.
DR PANTHER; PTHR42998; TYPE I RESTRICTION ENZYME HINDVIIP M PROTEIN-RELATED; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:CRK51697.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000044872};
KW Transferase {ECO:0000313|EMBL:CRK51697.1}.
FT DOMAIN 18..163
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 177..499
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 537 AA; 59060 MW; 772EE8883353CB45 CRC64;
MPPKKKVAVT APSTMKELKD TLWKAADKLR GSMDASQYKD VILGLVFLKY VSDAFAERRE
QIRAELVAEG LDENQIAQLI DDEDEYRAGG VFWVPDTARW DFLSTNAKGI AEAPGTAGRT
VGELIDGAMR HLMDANESLR GTLPTIFNSD SVDQRRLGEL VDLLGDTRFT GEGARKARDL
LGEVYEYFLE KFARAEGKRG GEFYTPAGVV RVLVEVLEPF GGRVYDPACG SGGMFVQTEK
FIEHHGGNAT DAAVYGQELN QRTWQMAKMN LAIHGVTGNL GDRWEDTFAQ DKHPDLLADY
VLANPPFNIK DWTRKEDDKR WKYGVPPIGN ANYAWIQHIV SKLAERGSAG IVMANGSMSS
NSGGEGDIRA QLVEADLVSC MVALPTQLFR STGIPVCVWF LAKDKGIGPK GSIDRQGQVL
FIDARNLGYM VDRAERALSD DDIAKIAGTV HAWRGTESAA GAAYEDEPGF CYSATLAEIK
EADYALTPGR YVGAAPIEDD GEPIDEKLAR LTGELYAQFD ESERLQKVVR EQLGRVL
//
