ID A0A0K3ARH3_BABMR Unreviewed; 459 AA.
AC A0A0K3ARH3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=E3 ubiquitin-protein ligase RBBP6 {ECO:0008006|Google:ProtNLM};
GN ORFNames=BMR1_03g02255 {ECO:0000313|EMBL:CTQ41050.1};
OS Babesia microti (strain RI).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC Babesiidae; Babesia.
OX NCBI_TaxID=1133968 {ECO:0000313|EMBL:CTQ41050.1, ECO:0000313|Proteomes:UP000002899};
RN [1] {ECO:0000313|EMBL:CTQ41050.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:CTQ41050.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=22833609; DOI=10.1093/nar/gks700;
RA Cornillot E., Hadj-Kaddour K., Dassouli A., Noel B., Ranwez V.,
RA Vacherie B., Augagneur Y., Bres V., Duclos A., Randazzo S., Carcy B.,
RA Debierre-Grockiego F., Delbecq S., Moubri-Menage K., Shams-Eldin H.,
RA Usmani-Brown S., Bringaud F., Wincker P., Vivares C.P., Schwarz R.T.,
RA Schetters T.P., Krause P.J., Gorenflot A., Berry V., Barbe V.,
RA Ben Mamoun C.;
RT "Sequencing of the smallest Apicomplexan genome from the human pathogen
RT Babesia microti.";
RL Nucleic Acids Res. 40:9102-9114(2012).
RN [2] {ECO:0000313|EMBL:CTQ41050.1, ECO:0000313|Proteomes:UP000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RI {ECO:0000313|EMBL:CTQ41050.1,
RC ECO:0000313|Proteomes:UP000002899};
RX PubMed=27752055; DOI=10.1038/srep35284;
RA Silva J.C., Cornillot E., McCracken C., Usmani-Brown S., Dwivedi A.,
RA Ifeonu O.O., Crabtree J., Gotia H.T., Virji A.Z., Reynes C., Colinge J.,
RA Kumar V., Lawres L., Pazzi J.E., Pablo J.V., Hung C., Brancato J.,
RA Kumari P., Orvis J., Tretina K., Chibucos M., Ott S., Sadzewicz L.,
RA Sengamalay N., Shetty A.C., Su Q., Tallon L., Fraser C.M., Frutos R.,
RA Molina D.M., Krause P.J., Ben Mamoun C.;
RT "Genome-wide diversity and gene expression profiling of Babesia microti
RT isolates identify polymorphic genes that mediate host-pathogen
RT interactions.";
RL Sci. Rep. 6:35284-35284(2016).
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DR EMBL; LN871598; CTQ41050.1; -; Genomic_DNA.
DR RefSeq; XP_012649061.1; XM_012793607.1.
DR AlphaFoldDB; A0A0K3ARH3; -.
DR GeneID; 24425093; -.
DR KEGG; bmic:BMR1_03g02255; -.
DR VEuPathDB; PiroplasmaDB:BMR1_03g02255; -.
DR OrthoDB; 150979at2759; -.
DR Proteomes; UP000002899; Chromosome IIIa.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:InterPro.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006301; P:postreplication repair; IEA:InterPro.
DR GO; GO:0006513; P:protein monoubiquitination; IEA:InterPro.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR039577; Rad18.
DR InterPro; IPR025829; Zn_knuckle_CX2CX3GHX4C.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14134; E3 UBIQUITIN-PROTEIN LIGASE RAD18; 1.
DR PANTHER; PTHR14134:SF2; E3 UBIQUITIN-PROTEIN LIGASE RAD18; 1.
DR Pfam; PF13696; zf-CCHC_2; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002899};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00047}.
FT DOMAIN 194..207
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 289..328
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 352..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..443
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 459 AA; 52205 MW; 5038D5B23EF2846B CRC64;
MEWRLKGTAG MFSTLSSKEN YKTVLEVRNA VKKAIGIPED GILDIVLYRN SNPHKPLSDL
ERVSVPEKFL VSRMSSAQAN QILMEAAKDF SGDEQSPDQS PSTNDDVTVL TTNLSANLSE
QKFDKNDTNN NLNGTSFVND DEDVKIASAM AAGGMDIQDT LQRRYYRNKT LQDPVKSQQK
MNQLQPEDKS TYICHMCGNP GHNIKDCTIV DGRRCEKKIR SATGIPVNFL RSIRQDEIQN
YKEVYILKDG TFAVMKDIST VSGEAYFNIS AEERISVSLG NQVKSQFKCP KCGNLLVDPM
TTLCCGETFC SVCLFQNKTS TIFPCPGCAR KIGVRYLEPN VALREVLKNS LENDKSAQTN
PNNQKNKINN KNSRSDDENE HITTRPFKDR KVNKHDHSHG NNENSRYNNR YNDRSKSRDF
RNDRVERCER DDKSDRHNHH YSRQRVLASE YISHYRKGG
//
