ID A0A0K3AWG6_CAEEL Unreviewed; 515 AA.
AC A0A0K3AWG6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Forkhead box protein O {ECO:0000256|ARBA:ARBA00039893};
GN Name=daf-16 {ECO:0000313|EMBL:CTQ86341.1,
GN ECO:0000313|WormBase:R13H8.1i};
GN ORFNames=CELE_R13H8.1 {ECO:0000313|EMBL:CTQ86341.1}, R13H8.1
GN {ECO:0000313|WormBase:R13H8.1i};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CTQ86341.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CTQ86341.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CTQ86341.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PROSITE-
CC ProRule:PRU00089}.
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DR EMBL; BX284601; CTQ86341.1; -; Genomic_DNA.
DR RefSeq; NP_001300402.1; NM_001313473.1.
DR AlphaFoldDB; A0A0K3AWG6; -.
DR SMR; A0A0K3AWG6; -.
DR EnsemblMetazoa; R13H8.1i.1; R13H8.1i.1; WBGene00000912.
DR AGR; WB:WBGene00000912; -.
DR WormBase; R13H8.1i; CE50870; WBGene00000912; daf-16.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000912; Expressed in larva and 5 other cell types or tissues.
DR ExpressionAtlas; A0A0K3AWG6; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd20032; FH_FOXO; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45767; FORKHEAD BOX PROTEIN O; 1.
DR PANTHER; PTHR45767:SF2; FORKHEAD BOX PROTEIN O; 1.
DR Pfam; PF00250; Forkhead; 1.
DR PRINTS; PR00053; FORKHEAD.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 1: Evidence at protein level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00089};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Proteomics identification {ECO:0007829|EPD:A0A0K3AWG6,
KW ECO:0007829|PeptideAtlas:A0A0K3AWG6};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 149..242
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 149..242
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 94..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 227..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56575 MW; EBE79AD0DA9BE0C0 CRC64;
MQAWNCRELD SPLPSDITLH NLEPARPDSG MSFSTDFDDD FFNLDLHQQE RSASFGGVTQ
YSQQFLREKC SFSPYFHTSL ETVDSGRTSL YGSNEQCGQL GGASSNGSTA MLHTPDGSNS
HQTSFPSEMS ESPDDTVSGK KTTTRRNAWG NMSYAELITT AIMASPEKRL TLAQVYEWMV
QNVPYFRDKG DSNSSAGWKN SIRHNLSLHS RFMRIQNEGA GKSSWWVINP DAKPGRNPRR
TRERSNTIET TTKAQLEKSR RGAKKRIKER ALMGSLHSTL NGNSIAGSIQ TISHDLYDDD
SMQGAFDNVP SSFRPRTQSN LSIPGSSSRV SPAIGSDIYD DLEFPSWVGE SVPAIPSDIV
DRTDQMRIDA TTHIGGVQIK QESKPIKTEP IAPPPSYHEL NSVRGSCAQN PLLRNPIVPS
TNFKPMPLPG AYGNYQNGGI TPINWLSTSN SSPLPGIQSC GIVAAQHTVA SSSALPIDLE
NLTLPDQPLM DTMDVDALIR HELSQAGGQH IHFDL
//