ID A0A0K3CL69_RHOTO Unreviewed; 730 AA.
AC A0A0K3CL69;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=BY PROTMAP: gi|472584210|gb|EMS21816.1| DNA mismatch repair protein MLH1 [Rhodosporidium toruloides NP11] {ECO:0000313|EMBL:CTR09437.1};
GN Name=FGENESH: predicted gene_10.135 {ECO:0000313|EMBL:CTR09437.1};
GN ORFNames=BN2166_0052980 {ECO:0000313|EMBL:CTR09437.1};
OS Rhodotorula toruloides (Yeast) (Rhodosporidium toruloides).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=5286 {ECO:0000313|EMBL:CTR09437.1, ECO:0000313|Proteomes:UP000199069};
RN [1] {ECO:0000313|EMBL:CTR09437.1, ECO:0000313|Proteomes:UP000199069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Single colony {ECO:0000313|EMBL:CTR09437.1};
RA Cajimat M.N.B., Milazzo M.L., Fulhorst C.F.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; CWKI01000010; CTR09437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K3CL69; -.
DR STRING; 5286.A0A0K3CL69; -.
DR OMA; ANYHVKK; -.
DR Proteomes; UP000199069; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000199069}.
FT DOMAIN 230..349
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 359..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 730 AA; 79460 MW; D96EF8F2F192D866 CRC64;
MATEKPAAPP APRAIAKLPE AVVNRIAAGE IIQRPSNALK ELIENSLDAG ATTIRVTVKE
GGLKLLQIQD NGSGIRKSDL PILCERFTTS KIKAFEDLSS LGTYGFRGEA LASISHVAHL
SVTTKTRDET CAWKAAYADG ALIPLKPGGD AAPLPCAGND GTVEDLFYNT PQRLRSLRPA
NEEYARILSV VTAYSIHNAG VSFVCKKTSS SSSSTGDVNT SIGASTLDNI GVLYGEAVRR
ELVEVQAVSE ELGVKVRAWC SGANYQAKRS TFLFFINHRY VDCTSLKRAL EAFYSTLLAK
NTHPFVYLSL SISPSKIDVN VHPTKKEVAF EDEDEVVQLV CEKLAEVLEK QGESRSYKVQ
TLLPTSGTPT APRTLAGSSA TATPAASTSR KPSTSSSTKP AKVAPNKLVR TDAQSQTLDA
MFPTLPTTST IRAGDKTREA ADDQDRSSKK RKSDHNPAFA SQLAAEQAAQ KSARVRIAQS
ECALTSVRQL RKEVVEARHE GLDALIKGHI FVGVADLETC KSMIQHQTKL YIVDHAAIGE
ELFYQLGLRH FGRFSRIKLQ PPQDLRKLVQ LAVDRASGGG AGNPAPPKIV ERVFSTLHGA
RAMLDEYFSF SISDDGKIES LPLVLPGYSP DMNKLPLFLL RIGAHVDWEH EKPCFATFLR
ELAFFYSPAP SPTAPPAPHS QDQVDAQKRT IQHVLFPAAK QYLVPPEKLL KKDVVLATSL
EALFRVFERC
//
