ID A0A0K6IN26_9PROT Unreviewed; 379 AA.
AC A0A0K6IN26;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=RND family efflux transporter, MFP subunit {ECO:0000313|EMBL:CUB04697.1};
GN ORFNames=Ga0061068_10136 {ECO:0000313|EMBL:CUB04697.1};
OS Tepidiphilus thermophilus.
OC Bacteria; Pseudomonadota; Hydrogenophilia; Hydrogenophilales;
OC Hydrogenophilaceae; Tepidiphilus.
OX NCBI_TaxID=876478 {ECO:0000313|EMBL:CUB04697.1, ECO:0000313|Proteomes:UP000182108};
RN [1] {ECO:0000313|Proteomes:UP000182108}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 19170 {ECO:0000313|Proteomes:UP000182108};
RA Babu N.S., Beckwith C.J., Beseler K.G., Brison A., Carone J.V.,
RA Caskin T.P., Diamond M., Durham M.E., Foxe J.M., Go M., Henderson B.A.,
RA Jones I.B., McGettigan J.A., Micheletti S.J., Nasrallah M.E., Ortiz D.,
RA Piller C.R., Privatt S.R., Schneider S.L., Sharp S., Smith T.C.,
RA Stanton J.D., Ullery H.E., Wilson R.J., Serrano M.G., Buck G., Lee V.,
RA Wang Y., Carvalho R., Voegtly L., Shi R., Duckworth R., Johnson A.,
RA Loviza R., Walstead R., Shah Z., Kiflezghi M., Wade K., Ball S.L.,
RA Bradley K.W., Asai D.J., Bowman C.A., Russell D.A., Pope W.H.,
RA Jacobs-Sera D., Hendrix R.W., Hatfull G.F.;
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CYHH01000001; CUB04697.1; -; Genomic_DNA.
DR RefSeq; WP_055422438.1; NZ_LIPU01000001.1.
DR AlphaFoldDB; A0A0K6IN26; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000182108; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000182108};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..379
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005505743"
FT DOMAIN 49..346
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 64..279
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 360..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 41097 MW; 4760952CD0BF9D12 CRC64;
MKSNTPLRLA LAAALVLLTA ACNRDDADAA KNQAAPPPPE VAVIEARYGS AVLRRELPGR
LEAYRTAQVR ARVEGILEKR FFEEGSDVKE GQLLYRIEPR TYQRAFEAAK ADVAAAKLLV
DRYRPLVKIN AISQQEFDSA EAAWKQAEAK LAQAALDLEN TRVPAPISGR IGRSLVTEGA
LVGKGEPTHL ATIEQIDPIY VNFTQPSAEL LALREALRSG QWKEADRSNV EIVLDNGKTY
PIPAKLLFED VSVDPATGAV LMRALAKNPE HVLLPGMFVR VRLPQMQMDK VITVPQRAVQ
INPQGHFVMV VDANNTVAPR AIKVGGMSGT DWVVLEGLQE GEKVVVEGLL KVRAGAPVKP
VPWQPKNTPA AAAPSTAAK
//
