ID A0A0K8JGI1_9FIRM Unreviewed; 677 AA.
AC A0A0K8JGI1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=DNA polymerase {ECO:0000313|EMBL:CUH96374.1};
DE EC=2.7.7.7 {ECO:0000313|EMBL:CUH96374.1};
GN Name=L3 {ECO:0000313|EMBL:CUH96374.1};
GN ORFNames=P22_2464 {ECO:0000313|EMBL:CUH96374.1};
OS Propionispora sp. 2/2-37.
OC Bacteria; Bacillota; Negativicutes; Selenomonadales; Sporomusaceae;
OC Propionispora.
OX NCBI_TaxID=1677858 {ECO:0000313|EMBL:CUH96374.1, ECO:0000313|Proteomes:UP000041641};
RN [1] {ECO:0000313|EMBL:CUH96374.1, ECO:0000313|Proteomes:UP000041641}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2/2 {ECO:0000313|EMBL:CUH96374.1};
RA Jackson K.R., Lunt B.L., Fisher J.N.B., Gardner A.V., Bailey M.E.,
RA Deus L.M., Earl A.S., Gibby P.D., Hartmann K.A., Liu J.E., Manci A.M.,
RA Nielsen D.A., Solomon M.B., Breakwell D.P., Burnett S.H., Grose J.H.;
RL Submitted (SEP-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
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DR EMBL; CYSP01000010; CUH96374.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K8JGI1; -.
DR STRING; 1677858.P22_2464; -.
DR Proteomes; UP000041641; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd08642; DNA_pol_A_pol_I_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:CUH96374.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000041641};
KW Transferase {ECO:0000313|EMBL:CUH96374.1}.
FT DOMAIN 399..643
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 677 AA; 75162 MW; 9379688A827E45A7 CRC64;
MRSRQIAAEG VNAAPSAASV KTEDISVNHI KSLSLDLETY SSVDLGKSGV YKYVESLDFE
IILFGYSIDG GEIKVVDLAN GETIPPEIVA ALTDENVMKW AFNAQFERIC LSKWLGLPTG
QYLDPRSWRC TMVWAAYMGL PLSLEGSGMV LGLEKQKLAE GRDLIRYFCQ PCKPTAANGQ
RTRNLPSHAP DKWAAFKAYN RRDVETEMSI QEKLTKFPVP DSVWAEYHID QAINDRGVAL
DMPFVQSAIQ ADERSRAELT RLMRELTELE NPNSVAQMKR WLAEHGLETD TLGKKAVTEL
LKTAPEPLGK ALELRQSLAK SSVKKYMAME NAVCADGRAR GMFQFYGANR TGRWAGRLIQ
LQNLPQNHML DLEQARSLVK SGNFAALDML YDSVPAVLSE LIRTAFIPKP GLKFIVADFS
AIEARVIAWL AGEKWRNEVF ATHGKIYEAS ASRMFHVPIE EITKGSPLRQ KGKIAELALG
YGGSVGALKT MGALDMGLSE EELRPLVAAW RSANPNIVKL WWGVDKAAMT AVRERTTSST
HGIRFECKSG MLFITLPSGR RLAYVKPRIG INQFGSDCVT YEGVGVAKKW KRIETYGPKL
VENIVQAISR DILCHAMGRL NSAGFPIVMS VHDEVVLEVT NGVSPEEVCR IMAETPPWAK
GLILRADGFM CPFYKKD
//
