ID A0A0K8QQ27_9GAMM Unreviewed; 790 AA.
AC A0A0K8QQ27;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:GAP66973.1};
GN ORFNames=MBSD_0645 {ECO:0000313|EMBL:GAN44125.1}, MBSD_n2289
GN {ECO:0000313|EMBL:GAP66973.1};
OS Mizugakiibacter sediminis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Rhodanobacteraceae; Mizugakiibacter.
OX NCBI_TaxID=1475481 {ECO:0000313|EMBL:GAP66973.1};
RN [1] {ECO:0000313|EMBL:GAN44125.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SkMP5 {ECO:0000313|EMBL:GAN44125.1};
RA Watanabe T., Kojima H., Fukui M.;
RT "Draft genome sequence of Mizugakiibacter sediminis skMP5.";
RL Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GAP66973.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SkMP5 {ECO:0000313|EMBL:GAP66973.1};
RA Rikkerink E.H.A., Fineran P.C.;
RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal
RT Agent of Kiwifruit Canker Disease.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; DF952378; GAN44125.1; -; Genomic_DNA.
DR EMBL; DF970239; GAP66973.1; -; Genomic_DNA.
DR RefSeq; WP_062537531.1; NZ_DF970239.1.
DR AlphaFoldDB; A0A0K8QQ27; -.
DR STRING; 1475481.GCA_000953855_02335; -.
DR HOGENOM; CLU_010448_0_0_6; -.
DR OrthoDB; 5389341at2; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000253740; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000253740}.
FT DOMAIN 10..193
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 196..295
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 790 AA; 85982 MW; 90C297340F8F5E95 CRC64;
MDLQPLRIRK AAVLGAGVMG AQIAAHLVNA DVDTVLFDLA AKEGPKNGIA QRAIANLAKL
SPAPLAERTR GAAIVPADYD EHLDLLKDCD LVIEAIAERM DWKLDLYRRI APHLPAHAIV
ASNTSGLSIN TLAEAVPEAI RHRFCGVHFF NPPRYMHLVE LIPNRLTDRA VLEGLEAFLT
TTLGKGVVYA KDTPNFIGNR IGVFSILATM HHTERFGLGF DVVDALTGPA IGRPKSATYR
TADVVGLDTM AHVIKTMADT LPDDPWHGYF KSPAWLQALI DQGALGQKSG AGFYRKAGKD
IVVLDLAKRD YRPSAQKASD EVAAILAIKD PAGKFAKLRA SADREAQFLW AVFRDLFHYT
AYHLADIADT ARDVDFAIRW GYGWKLGPFE TWQAAGWRQV AGWIAEDIAA GKAMSRAPLP
AWVTDGREGV HDRDGSFAPR SGKLEARSRH PVYRRQLFPD PLLGERFDTG TTIWENDGIR
LWHLGDDIAI TSFKTKMNTV NDAVLDGLQR AVEEAERGCK ALVLWQTGEP FSAGADLKGA
MGLLQAGKLA EFEAMIANFQ ATSMKLKYAL VPVVAAIRGM ALGGGCEFQM HSARTVAALE
SYIGLVEAGV GLLPAGGGLK EIALRCSRAA PDGDPFPQIK RWFETVAMAK VSGSALEAKQ
MGLLRDSDVV VFNGHELLYV AKQVAAAMAE SGYRPPLPAR DIVVAGDVGA ASLKMMLVNM
LEGRFVSPHD YEVASRIADT LCGGQIERGS QVDEAWLLDL ERKHFVQLAQ MPKTQERIVH
TLATGKPLRN
//
