ID A0A0K8QRW1_9GAMM Unreviewed; 609 AA.
AC A0A0K8QRW1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=MBSD_n2745 {ECO:0000313|EMBL:GAP67421.1};
OS Mizugakiibacter sediminis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Rhodanobacteraceae; Mizugakiibacter.
OX NCBI_TaxID=1475481 {ECO:0000313|EMBL:GAP67421.1};
RN [1] {ECO:0000313|EMBL:GAP67421.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SkMP5 {ECO:0000313|EMBL:GAP67421.1};
RA Rikkerink E.H.A., Fineran P.C.;
RT "Complete DNA Sequence of Pseudomonas syringae pv. actinidiae, the Causal
RT Agent of Kiwifruit Canker Disease.";
RL Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; DF970270; GAP67421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K8QRW1; -.
DR STRING; 1475481.GCA_000953855_02791; -.
DR Proteomes; UP000253740; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000253740}.
FT DOMAIN 222..340
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 422..565
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 609 AA; 65563 MW; 6CBD09E3AA8E8063 CRC64;
MLGGLAHRPA MPQIRPLPPE LVNQIAAGEV IERPASVVKE LVENSLDAGA ARVEIDIEEG
GARLIRVRDD GSGIAADELA LAVASHATSK IASFADLERV ATLGFRGEAL PSIASVSRFA
LTSRPRAQDT AFRLEVDGGR AQAPRPAPHP PGSSVEVRDL FYNVPARRKF LRAERTEFGH
IDELVKTLAL ARAQVEFRLG HNGRPVRLFK PARDEAAALA RVAEVLGPDF PAQSLRVEQR
AAGLALSGWV GLPTAARAQP DQQYFFVNGR MVRDRVVAHA VRQAYADVLF HGRHPAFVLF
LELDPEAVDV NVHPAKHEVR FREARLVHDF LFRTLHEAIA GTRAGATAPQ LAVAPPASAS
APAQRSDPWR GQAPLRLGVR EAPGDPYAAL LGATQAAPAA ASPAMPPQPQ PQDGAPPPLG
FALAQLAGIY ILAENAEGLV LVDMHAAHER VTYEKLKAAQ ACDGIRSQLL LVPLVLAVSE
REAAAAEEHA ETLAALGLEL DRSGPQQVTV RRMPALLDGA DAAQLARDVL ADLVAHGSSR
RLEALQNELL STMACHGSVR AHRRLTLPEM NALLREMEAT ERSGQCNHGR PTWTQLSVAE
LDRLFMRGR
//
