ID A0A0K9F540_9BACI Unreviewed; 304 AA.
AC A0A0K9F540;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=High-affinity heme uptake system protein IsdE {ECO:0000256|ARBA:ARBA00015862};
DE AltName: Full=Iron-regulated surface determinant protein E {ECO:0000256|ARBA:ARBA00031463};
DE AltName: Full=Staphylococcal iron-regulated protein F {ECO:0000256|ARBA:ARBA00031148};
GN ORFNames=ACZ11_19465 {ECO:0000313|EMBL:KMY29283.1};
OS Lysinibacillus xylanilyticus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=582475 {ECO:0000313|EMBL:KMY29283.1, ECO:0000313|Proteomes:UP000037326};
RN [1] {ECO:0000313|Proteomes:UP000037326}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23493 {ECO:0000313|Proteomes:UP000037326};
RG Consortium for Microbial Forensics and Genomics (microFORGE);
RA Knight B.M., Roberts D.P., Lin D., Hari K., Fletcher J., Melcher U.,
RA Blagden T., Winegar R.A.;
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
CC -!- SIMILARITY: Belongs to the bacterial solute-binding protein 8 family.
CC {ECO:0000256|ARBA:ARBA00008814}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMY29283.1}.
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DR EMBL; LFXJ01000010; KMY29283.1; -; Genomic_DNA.
DR RefSeq; WP_049668190.1; NZ_LFXJ01000010.1.
DR AlphaFoldDB; A0A0K9F540; -.
DR PATRIC; fig|582475.4.peg.2963; -.
DR OrthoDB; 66025at2; -.
DR Proteomes; UP000037326; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0015886; P:heme transport; IEA:InterPro.
DR Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 2.
DR InterPro; IPR019957; ABC_transptr_haem-bd_IsdE.
DR InterPro; IPR002491; ABC_transptr_periplasmic_BD.
DR NCBIfam; TIGR03659; IsdE; 1.
DR PANTHER; PTHR30535:SF36; HIGH-AFFINITY HEME UPTAKE SYSTEM PROTEIN ISDE; 1.
DR PANTHER; PTHR30535; VITAMIN B12-BINDING PROTEIN; 1.
DR Pfam; PF01497; Peripla_BP_2; 1.
DR SUPFAM; SSF53807; Helical backbone' metal receptor; 1.
DR PROSITE; PS50983; FE_B12_PBP; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Heme {ECO:0000256|ARBA:ARBA00022617}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..304
FT /note="High-affinity heme uptake system protein IsdE"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5039132754"
FT DOMAIN 51..304
FT /note="Fe/B12 periplasmic-binding"
FT /evidence="ECO:0000259|PROSITE:PS50983"
SQ SEQUENCE 304 AA; 34023 MW; 4A7D100226BCC7A4 CRC64;
MQKNWKCWLL MMALMSLLLV VAGCNDGDKR EEKETSAEEQ LSKTAEENEQ RIIAGTVVIA
EILDKLDIDA IAVPETEKTL AKRFDGLPTI GNAMEPDMEI VKSLNPTDVL SVSTLEYDLQ
DKFEQLKIPV DFLNFQSVDA MLSEIRTLGE RYDRVAQADE LVNGLQKNID AVQTVAGNKK
GPRVLILLGI PGSYLVATEN SYAGDLVKRA GGINVMEGQD AEYLSSNTEY LHNSNPDIIL
RLSHGMPDEV VKMFDEEFKT NDIWKHFDAV KNGKVYDLEE ELFGTTASLK VPQALGRLME
IFYR
//
