ID A0A0K9NT46_ZOSMR Unreviewed; 484 AA.
AC A0A0K9NT46;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Putative Hydroxysteroid dehydrogenase {ECO:0000313|EMBL:KMZ59808.1};
GN ORFNames=ZOSMA_64G00230 {ECO:0000313|EMBL:KMZ59808.1};
OS Zostera marina (Eelgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zosteraceae; Zostera.
OX NCBI_TaxID=29655 {ECO:0000313|EMBL:KMZ59808.1, ECO:0000313|Proteomes:UP000036987};
RN [1] {ECO:0000313|Proteomes:UP000036987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Finnish {ECO:0000313|Proteomes:UP000036987};
RX PubMed=26814964; DOI=10.1038/nature16548;
RA Olsen J.L., Rouze P., Verhelst B., Lin Y.-C., Bayer T., Collen J.,
RA Dattolo E., De Paoli E., Dittami S., Maumus F., Michel G., Kersting A.,
RA Lauritano C., Lohaus R., Toepel M., Tonon T., Vanneste K., Amirebrahimi M.,
RA Brakel J., Bostroem C., Chovatia M., Grimwood J., Jenkins J.W.,
RA Jueterbock A., Mraz A., Stam W.T., Tice H., Bornberg-Bauer E., Green P.J.,
RA Pearson G.A., Procaccini G., Duarte C.M., Schmutz J., Reusch T.B.H.,
RA Van de Peer Y.;
RT "The genome of the seagrass Zostera marina reveals angiosperm adaptation to
RT the sea.";
RL Nature 530:331-335(2016).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMZ59808.1}.
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DR EMBL; LFYR01001714; KMZ59808.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K9NT46; -.
DR STRING; 29655.A0A0K9NT46; -.
DR OMA; YFPLDEH; -.
DR OrthoDB; 5487986at2759; -.
DR Proteomes; UP000036987; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028110; TMEM254.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF14934; TMEM254; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000036987};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 385..404
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..294
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 484 AA; 54209 MW; 175DBE5631BA6A7C CRC64;
MQQLNEREGI EGRAFTVTGG LGFVGSVLCL ALVRRGARSV RSLDLRSSSS WSDDLQTAGV
RCIQGDVSNK KDVERAVGGV DCVFHLASYG MSGKEMIQTQ LIDKINIGGT CNVIDACFVK
GISRLVYVST YNVVFGGKEI VNGNEFLPYF PIEDHVDSYG RSKSVAEQLV LKSNGRQLKD
DKGRMLYTCA VRPAAIYGPG EERHLPRILS LAKRDLLFFK IGKEDVKTDW VYVDNLVLAL
IQASMGLLDD IPDRKGQRPV ASGQAYFISD GSPINTFDSL IIPLVRSLSY GLPKYTLGVK
DALRLSDFFF VLYIMLFPWL NRPWLPQPLL LPAEVYKVGV THYFSYVKAK DELGYVPMVS
PQDGLAATIS YWQKRKMREL DNPPLYLVLL IVLGMTLLCC VTYLPPYGPL KYVLAVGLFF
FRSQWGLHVL FVSSVIAHVA EALYAWNIAK RVDSANSKGW FWQTLLVGYP SLRLLKRRQT
KQVN
//
