ID A0A0K9PG28_ZOSMR Unreviewed; 507 AA.
AC A0A0K9PG28;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Metal tolerance protein C1 {ECO:0000313|EMBL:KMZ68033.1};
GN ORFNames=ZOSMA_24G00540 {ECO:0000313|EMBL:KMZ68033.1};
OS Zostera marina (Eelgrass).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Zosteraceae; Zostera.
OX NCBI_TaxID=29655 {ECO:0000313|EMBL:KMZ68033.1, ECO:0000313|Proteomes:UP000036987};
RN [1] {ECO:0000313|Proteomes:UP000036987}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Finnish {ECO:0000313|Proteomes:UP000036987};
RX PubMed=26814964; DOI=10.1038/nature16548;
RA Olsen J.L., Rouze P., Verhelst B., Lin Y.-C., Bayer T., Collen J.,
RA Dattolo E., De Paoli E., Dittami S., Maumus F., Michel G., Kersting A.,
RA Lauritano C., Lohaus R., Toepel M., Tonon T., Vanneste K., Amirebrahimi M.,
RA Brakel J., Bostroem C., Chovatia M., Grimwood J., Jenkins J.W.,
RA Jueterbock A., Mraz A., Stam W.T., Tice H., Bornberg-Bauer E., Green P.J.,
RA Pearson G.A., Procaccini G., Duarte C.M., Schmutz J., Reusch T.B.H.,
RA Van de Peer Y.;
RT "The genome of the seagrass Zostera marina reveals angiosperm adaptation to
RT the sea.";
RL Nature 530:331-335(2016).
CC -!- FUNCTION: Involved in sequestration of excess metal in the cytoplasm
CC into vacuoles to maintain metal homeostasis.
CC {ECO:0000256|ARBA:ARBA00003168}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily.
CC {ECO:0000256|ARBA:ARBA00008873}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KMZ68033.1}.
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DR EMBL; LFYR01000864; KMZ68033.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0K9PG28; -.
DR STRING; 29655.A0A0K9PG28; -.
DR OMA; IVNFHCR; -.
DR OrthoDB; 5489381at2759; -.
DR Proteomes; UP000036987; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 2.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR43840:SF15; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000036987};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT DOMAIN 294..367
FT /note="Cation efflux protein cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF16916"
SQ SEQUENCE 507 AA; 55638 MW; A3595D9AA12D7AD4 CRC64;
MKFRFSNLTV AYRTARSLSR TARSHYFGRH IVHPIFVTED RSCLKTSRRW HGGHSHHHGG
RDENDGIFKL GLAADVGLAV GKALTGYASG STAIIADAAH SISDIVLSGV ALLSYRAARA
PKDKEHPYGH GKFETLGALG ISCMLLATAG GIAWHALGIL HSVLISNPDI IDHSLLDNHN
HGGHNHAIDL DHPVLALNMT ITSIAVKEGL YWITKRAGDK EGGGLLMKAN AWHHRADAVS
SVVALVGVGG AILGVRFLDP LAGLVVSGMI FKAGIKSGYE SVMELVDAGV PFSTLAPIKR
TIIEVEGVMG SHRLRGRKAG SSIYLDVHVE VDPFLSVSMA HNIGENVRHQ IHKCHRNIAE
VFIHIDPSFE YFETTLDKRK ETSNFILNEN SSYSKEENQK TLVSNILSSQ FSKKISVEHI
TRHLLQGKVF LQIQVSMPSN MLIIDATTIA KEAEKEILKA DSSINQVSIQ LRLGEQTPQF
NNHLNKKNNH NTELYMLQNF TNPQQSE
//
