ID   A0A0K9XJI0_9ACTN        Unreviewed;      1129 AA.
AC   A0A0K9XJI0;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Phenyloxazoline synthase MbtB {ECO:0000256|ARBA:ARBA00016743};
DE   AltName: Full=Mycobactin synthetase protein B {ECO:0000256|ARBA:ARBA00033440};
GN   ORFNames=AC230_09195 {ECO:0000313|EMBL:KNB52807.1};
OS   Streptomyces caatingaensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1678637 {ECO:0000313|EMBL:KNB52807.1, ECO:0000313|Proteomes:UP000037288};
RN   [1] {ECO:0000313|Proteomes:UP000037288}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMAA 1322 {ECO:0000313|Proteomes:UP000037288};
RA   Santos S.N., Gacesa R., Taketani R.G., Long P.F., Melo I.S.;
RT   "Draft genome sequence of Streptomyces sp. CMAA 1322, a bacterium isolated
RT   from Caatinga biome, from dry forest semiarid of Brazil.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005102}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       MbtB subfamily. {ECO:0000256|ARBA:ARBA00007380}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KNB52807.1}.
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DR   EMBL; LFXA01000004; KNB52807.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0K9XJI0; -.
DR   STRING; 1678637.AC230_09195; -.
DR   PATRIC; fig|1678637.3.peg.1988; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000037288; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR   CDD; cd12114; A_NRPS_TlmIV_like; 1.
DR   CDD; cd19535; Cyc_NRPS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.980; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 1.10.10.1830; Non-ribosomal peptide synthase, adenylation domain; 1.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020459; AMP-binding.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR041464; TubC_N.
DR   InterPro; IPR044894; TubC_N_sf.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   PANTHER; PTHR45527:SF10; PHENYLOXAZOLINE SYNTHASE MBTB; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF18563; TubC_N; 1.
DR   PRINTS; PR00154; AMPBINDING.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037288}.
FT   DOMAIN          1045..1125
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   1129 AA;  123010 MW;  71EA7AC05A28546B CRC64;
     MEDLLVELRN RRVTLRLNGD RLDIEAPDDA LTPRLRAAVD EHRDELVALL RGRPRPAGLP
     AARPEPGLRG DPFPLTDIQH AYLIGRHQGL ELGGVASHYY YEFDGTGLDV PRLSEALRKV
     VARHDMLRAV VQPGGRQRVL EQVPPYEIAA QDLRGRTAAE QAEALDRVRG ELADQVLPTE
     EWPPFDIRAS LLDEDRVRLH LSMDLLFVDV RSLFVVLDEW RRFYDDPAWE PEPLELSFRD
     YVLAEQALES EALGKKSADY WLSRVDELPP GPDLPIGTAP ERLGRPAFTR RRAVLAPERW
     AALSDAAHRH GLTPDNLLLA AYAEVLRTWS RRQEFTLTLT QLHRLPLHPQ AQKIVGDFLS
     PGLLAVGGTA GETFAERAAG LQRQRLADLA HSAFGGIRVL RELTRRQGDG RNVSMPVVHS
     SMLGAEGDAA TADALRLFGD VAYGISQTPQ VWLENQVTEE NGELVLTWNA VDGLFPEGTL
     DAMFDAYTTL LGGLAEGEEV WSAAGGVVPL PAEQLAERQR ANDTARDIPP ALLHELVAAA
     ARRTPDAVAV LAGGTETTYR ELTEDAHRLA RRLREVCGAE PNTVIAVSTR PGPGQISALL
     GVQHAGAAYV AIDPELPEQR RLKLLRQCKA RAVVTEPALR TELTWPDGVE LVTLDDAATR
     AQDAGPVESA QGVDDLAYVI FTSGSTGEPK GVMISHRNAA NTVQDINDRF AVTGSDRVLA
     LAPTGFDLSV YDIFGVLGAG GAIVVPDPKR ANDPAHWTEL IDRHGVTVWN SVPAPMRMWV
     ETMTDAAPGS GASLRLALLS GDWIPLDLPG RLRERFPRLQ AVSLGGATEG SIWSIHHPIG
     EVPADWSSIP YGTPLANQVF HVYNEWLEPC PTGVTGELYI GGTGVAQGYW ADPVRTAERF
     ITHPATGERL YRTGDLGRYR PGGTIEILGR TDFQVKINGY RVELGEIEAT LLRQEGVRQA
     LVTAPAHPRT GQRQLAAYLV VDEPGAAHLD PAALRETLAG DLPGYMVPTH YLTLDAVPLT
     PNGKVDQGAL PTPWNEAEDG DGRVSPRNAI EERLLTLWAE QLGHADFGIE DGFFDVGGDS
     LHAVGIIGHL RTEFGIDASA EQEVIEGLFM NATIADFAEI IVSIKEAGA
//