ID A0A0K9XK01_9ACTN Unreviewed; 404 AA.
AC A0A0K9XK01;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:KNB53643.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:KNB53643.1};
GN ORFNames=AC230_03195 {ECO:0000313|EMBL:KNB53643.1};
OS Streptomyces caatingaensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1678637 {ECO:0000313|EMBL:KNB53643.1, ECO:0000313|Proteomes:UP000037288};
RN [1] {ECO:0000313|Proteomes:UP000037288}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CMAA 1322 {ECO:0000313|Proteomes:UP000037288};
RA Santos S.N., Gacesa R., Taketani R.G., Long P.F., Melo I.S.;
RT "Draft genome sequence of Streptomyces sp. CMAA 1322, a bacterium isolated
RT from Caatinga biome, from dry forest semiarid of Brazil.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNB53643.1}.
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DR EMBL; LFXA01000002; KNB53643.1; -; Genomic_DNA.
DR RefSeq; WP_049714366.1; NZ_LFXA01000002.1.
DR AlphaFoldDB; A0A0K9XK01; -.
DR STRING; 1678637.AC230_03195; -.
DR PATRIC; fig|1678637.3.peg.702; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000037288; Unassembled WGS sequence.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:KNB53643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037288};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:KNB53643.1}.
FT DOMAIN 6..230
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 283..403
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 93
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 360
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 390
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 404 AA; 41918 MW; B77A0D0476E1159D CRC64;
MSTEAYVYDA IRTPRGRGKA NGSLHGTKPI DLVVGLIHEL LRRFPGLDPA AIDDIVLGVV
SPVGEQGSDI ARIAAVAAGL PDTVAGVQEN RFCASGLEAV NLAAAKVRSG WEDLVLAGGV
ESMSRVPMAS DGGAWFGDPL TNFATGFVPQ GIGADLIATL GGFGRHDVDV FAARSQERAA
AAWKEGRFDR SVVPVRDRAG LVVLDRDEHL RPGTTPETLA SLKPSFAAIG EAGGFDAVAL
QKYHWVERID HVHHAGNSSG IVDGASLVAI GSREVGERYG LVPRARIVSA AVSGSEPTIM
LTGPAPATRK ALAKAGLTID DIDLVEVNEA FAAVVLRFVD EMGVDMDRVN VNGGAIALGH
PLGATGAMLL GTVIDELERT GGRFGLVTLC VGGGMGVATV VERV
//
